Stimulus-response diversity in local neuronal populations of the cerebral cortex

Neuroreport
O V Favorov, D G Kelly

Abstract

In cortex, neighboring 0.05 mm minicolumns have distinctly different receptive fields (RFs). Within minicolumns, neighboring cells have very similar RFs, but differ prominently in their stimulus-evoked temporal behaviors. This is reproduced in a cortical model that has strong inhibition and semi-random lateral connections among cells with similar RFs. Within modeled minicolumns, non-linear dynamics amplify small differences in cells' lateral inputs into large differences in temporal behaviors. Cells' stimulus-evoked behaviors, though complex, are surprisingly orderly, in that (1) time courses of cells' responses are very stimulus-specific and (2) in the presence of a stimulus, activities of some cells fluctuate coherently, and the patterns of coherence are also stimulus-specific. Thus the model, like real cortex, represents stimulus information in the overall strengths and temporal patterns of cells' responses and in patterns of temporal coherence among cells.

Citations

Oct 3, 2002·Behavioural Brain Research·O V FavorovM Tommerdahl
Sep 30, 1998·Current Opinion in Neurobiology·Y Iwamura
Mar 10, 2004·Neural Computation·Jörg Lücke, Christoph von der Malsburg
Dec 15, 2017·Frontiers in Computational Neuroscience·Yuwei CuiJeff Hawkins
Apr 19, 2002·Brain : a Journal of Neurology·Daniel P Buxhoeveden, Manuel F Casanova
May 1, 2021·Military Medicine·Mark TommerdahlTimothy B Bentley

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Trends in Neurosciences
N V Swindale
Brain : a Journal of Neurology
V B Mountcastle
Neural Networks : the Official Journal of the International Neural Network Society
Jörg Lücke
© 2021 Meta ULC. All rights reserved