PMID: 2504287Sep 19, 1989Paper

Stimulus-secretion coupling of arginine-induced insulin release. Functional response of islets to L-arginine and L-ornithine

Biochimica Et Biophysica Acta
F BlachierW J Malaisse

Abstract

L-Arginine and L-ornithine stimulate insulin release from pancreatic islets exposed to D-glucose. This coincides with an increased outflow of 86Rb and 45Ca from prelabelled islets and an increased net uptake of 45Ca by the islets. In the presence of D-glucose, L-lysine stimulates insulin secretion to the same extent as L-arginine or L-ornithine, but the hormonal release is not further enhanced by combinations of these cationic amino acids. L-Arginine or L-ornithine failed to enhance insulin release evoked by either L-leucine or 2-ketoisocaproate. The inhibitor of ornithine decarboxylase D,L-alpha-difluoromethyl ornithine failed to affect the metabolism and insulinotropic action of D-glucose in pancreatic islets, and only caused a partial inhibition of the secretory response to either L-arginine or L-ornithine. The latter amino acids inhibited modestly but significantly D-glucose utilization and oxidation by pancreatic islets. These and complementary findings suggest that the secretory response to L-arginine and L-ornithine is not attributable to any major change in the overall oxidative catabolism of nutrients, but involves mainly a biophysical component, such as the depolarization of the plasma membrane by these cationic amino...Continue Reading

References

Jul 1, 1985·Cell Biochemistry and Function·P C MathiasW J Malaisse
Oct 15, 1984·Experientia·E GylfeB Täljedal
Jul 1, 1980·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J C HuttonW J Malaisse
Jun 1, 1981·Endocrinology·V Leclercq-MeyerW J Malaisse

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Citations

Mar 15, 1996·Experientia·A M Svensson, L Jansson
Feb 5, 2000·Diabetes Research and Clinical Practice·S H Lee, I S Park
Jan 24, 2014·Journal of the Science of Food and Agriculture·Jeong-Eun ParkYoun-Soo Cha
Mar 21, 2003·Metabolism: Clinical and Experimental·Christina SchneidSylviane Darquy
Dec 28, 2002·Diabetes Care·Adrien SchaeferGabrielle Brandenberger
Jul 15, 1997·The Journal of Physiology·C VillalobosJ García-Sancho
Jul 10, 2007·General and Comparative Endocrinology·Olga HrytsenkoBill Pohajdak
Nov 4, 2016·Amino Acids·Antonio Herbert LanchaFrancois Blachier
Jan 1, 1994·Medicinal Research Reviews·J F Kerwin, M Heller
Oct 27, 2005·American Journal of Physiology. Endocrinology and Metabolism·Nobuyoshi IshiyamaJean-Claude Henquin
Dec 1, 2006·The Journal of Biological Chemistry·Toyoyoshi UchidaHirotaka Watada
Nov 14, 2013·Critical Reviews in Food Science and Nutrition·Wendy R RussellMartin O Weickert
Dec 25, 2013·International Journal of Molecular Medicine·Willy J Malaisse
May 22, 2019·Diabetes/metabolism Research and Reviews·Khemayanto HidayatBi-Min Shi
Sep 11, 1992·International Journal of Sport Nutrition·L R BucciJ M Pivarnik
Jun 3, 2018·Amino Acids·Catherine J McNealGuoyao Wu
Jun 29, 2000·The American Journal of Clinical Nutrition·L J van LoonA J Wagenmakers
Jan 28, 2020·Seminars in Cell & Developmental Biology·Anna Wendt, Lena Eliasson
Jul 1, 1995·The American Journal of Physiology·J M EganM Bernier
Jan 1, 1990·Metabolism: Clinical and Experimental·G MarynissenW J Malaisse

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