Stimulus site and modality dependence of functional activity within the human spinal cord.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
J C W BrooksIrene Tracey

Abstract

Chronic pain is thought to arise because of maladaptive changes occurring within the peripheral nervous system and CNS. The transition from acute to chronic pain is known to involve the spinal cord (Woolf and Salter, 2000). Therefore, to investigate altered human spinal cord function and translate results obtained from other species, a noninvasive neuroimaging technique is desirable. We have investigated the functional response in the cervical spinal cord of 18 healthy human subjects (aged 22-40 years) to noxious thermal and non-noxious tactile stimulation of the left and right forearms. Physiological noise, which is a significant source of signal variability in the spinal cord, was accounted for in the general linear model. Group analysis, performed using a mixed-effects model, revealed distinct regions of activity that were dependent on both the side and the type of stimulation. In particular, thermal stimulation on the medial aspect of the wrist produced activity within the C6/C5 segment ipsilateral to the side of stimulation. Similar to data recorded in animals (Fitzgerald, 1982), painful thermal stimuli produced increased ipsilateral and decreased contralateral blood flow, which may reflect, respectively, excitatory and in...Continue Reading

Citations

Aug 7, 2014·ELife·Robert L BarryJohn C Gore
Dec 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Yazhuo KongJonathan C W Brooks
Apr 23, 2015·Proceedings of the National Academy of Sciences of the United States of America·Li Min ChenJohn C Gore
Apr 9, 2013·Journal of Bodywork and Movement Therapies·Matt Wallden
Jan 7, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Tanya Verma, Julien Cohen-Adad
Jul 19, 2013·NeuroImage·C A Wheeler-KingshottI Tracey
Aug 27, 2013·Pain·Paul Eugene SummersFederico Giove
Oct 4, 2016·NeuroImage·Falk EippertJonathan C W Brooks
Oct 27, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Jonathan C W Brooks
Nov 7, 2015·Magnetic Resonance Insights·Tiffany A KolesarJennifer Kornelsen
Sep 12, 2018·Brain Sciences·Jocelyn M PowersPatrick W Stroman
Nov 10, 2018·Scientific Reports·Robert L BarryJohn C Gore
May 13, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Thierry PaquetteMathieu PichÉ

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