Stimulus-transcription coupling in neurons: role of cellular immediate-early genes.

Trends in Neurosciences
J I Morgan, T Curran

Abstract

Excitation of neurons results in a series of finely orchestrated responses that occur over a time frame ranging from fractions of a second to hours or days. In the short term, stimulation evokes an array of biochemical and biophysical events that represent the execution of the neurophysiological phenotype of a particular cell. These processes, which contribute to the overall behavior of a neural circuit, do not require de novo protein synthesis. In contrast, stimulation is also linked to long-term phenotypic changes that require alterations in gene expression. Thus, one or more mechanisms must exist that couple cell-surface stimuli to the transcriptional regulatory apparatus of the neuron. In this article James Morgan and Tom Curran detail a stimulus-transcription coupling cascade, involving the products of the proto-oncogenes, c-fos and c-jun, that operates in many cell types including neurons.

References

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Citations

Mar 11, 1996·The Journal of Comparative Neurology·L L Bellavance, A J Beitz
Apr 29, 1998·The Journal of Comparative Neurology·C V Mello, S Ribeiro
Feb 6, 1999·The Journal of Comparative Neurology·R L Saint MarieA F Ryan
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Nov 26, 2009·Brain Structure & Function·Miklós PalkovitsTed B Usdin
Feb 2, 2006·Cell and Tissue Research·Hirofumi Kuramoto, Makoto Kadowaki
Mar 30, 2007·Cellular and Molecular Neurobiology·Lenise Trito Garcia da SilveiraMaria José A Rocha
May 3, 1990·European Journal of Pharmacology·J M Séquier, M Lazdunski

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