STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.

Nature
Hiroki Ishikawa, Glen N Barber

Abstract

The cellular innate immune system is essential for recognizing pathogen infection and for establishing effective host defence. But critical molecular determinants responsible for facilitating an appropriate immune response-following infection with DNA and RNA viruses, for example-remain to be identified. Here we report the identification, following expression cloning, of a molecule (STING; stimulator of interferon genes) that appears essential for effective innate immune signalling processes. It comprises five putative transmembrane regions, predominantly resides in the endoplasmic reticulum and is able to activate both NF-kappaB and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta ) and exert a potent anti-viral state following expression. In contrast, loss of STING rendered murine embryonic fibroblasts extremely susceptible to negative-stranded virus infection, including vesicular stomatitis virus. Further, STING ablation abrogated the ability of intracellular B-form DNA, as well as members of the herpesvirus family, to induce IFN-beta, but did not significantly affect the Toll-like receptor (TLR) pathway. Yeast two-hybrid and co-immunoprecipitation studies indicated that STING int...Continue Reading

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Citations

Dec 17, 2010·Cellular and Molecular Life Sciences : CMLS·Hiroki Ishikawa, Glen N Barber
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Methods Mentioned

BETA
confocal microscopy
two-hybrid
co-immunoprecipitation
PCR
ELISA
Transgenic
two Hybrid

Software Mentioned

GeneSpring
EvoQuest

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