STK38 at the crossroad between autophagy and apoptosis.

Autophagy
Carine JoffreJacques Camonis

Abstract

We describe the STK38 protein kinase as a conserved regulator of autophagy. We discovered STK38 as a novel binding partner of Beclin1, a key regulator of autophagy. By combining molecular, cell biological and genetic approaches, we show that STK38 promotes autophagosome formation in human cells and in Drosophila. Furthermore, we also provide evidence demonstrating that STK38 with the small GTPase RalB, assist the co-ordination between autophagic and apoptotic events upon autophagy induction, hence proposing a role for STK38 in determining cellular fate in response to autophagic conditions.

Citations

May 24, 2016·Genes·Alexander Hergovich
Jun 22, 2019·Scientific Reports·Manish Kumar SinghMaria Carla Parrini
Apr 9, 2020·Frontiers in Cell and Developmental Biology·Juan Carlos Duhart, Laurel A Raftery
Nov 5, 2020·Cellular and Molecular Life Sciences : CMLS·Alexandre Pj MartinJacques H Camonis
Aug 8, 2021·International Journal of Molecular Sciences·Talita de S LaurentinoSueli M Oba-Shinjo

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Methods Mentioned

BETA
GTPase

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