Stochastic and regulatory role of chromatin silencing in genomic response to environmental changes.

PloS One
Jung Kyoon ChoiYoung-Joon Kim

Abstract

Phenotypic diversity and fidelity can be balanced by controlling stochastic molecular mechanisms. Epigenetic silencing is one that has a critical role in stress response. Here we show that in yeast, incomplete silencing increases stochastic noise in gene expression, probably owing to unstable chromatin structure. Telomere position effect is suggested as one mechanism. Expression diversity in a population achieved in this way may render a subset of cells to readily respond to various acute stresses. By contrast, strong silencing tends to suppress noisy expression of genes, in particular those involved in life cycle control. In this regime, chromatin may act as a noise filter for precisely regulated responses to environmental signals that induce huge phenotypic changes such as a cell fate transition. These results propose modulation of chromatin stability as an important determinant of environmental adaptation and cellular differentiation.

References

May 6, 1999·The EMBO Journal·J Pérez-MartínA D Johnson
Aug 10, 2000·Cell·T R HughesS H Friend
Nov 9, 2000·Genes & Development·A D WatsonS Y Roth
Dec 2, 2000·Nature Genetics·M PrimigR E Esposito
Dec 5, 2000·Molecular Biology of the Cell·A P GaschP O Brown
Jun 16, 2001·Science·J A BaurW E Wright
Apr 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yulei WangPatrick O Brown
Jun 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Bradley E BernsteinStuart L Schreiber
Jun 14, 2002·Gene·Boris Magasanik, Chris A Kaiser
Dec 31, 2002·Molecular Cell·Wandong AiX F Steven Zheng
Oct 4, 2003·The Journal of Biological Chemistry·Judith K DavieSharon Y R Dent
Jan 1, 1992·Trends in Cell Biology·L L Sandell, V A Zakian
Mar 10, 2004·Cell·Andrew D BasehoarB Franklin Pugh
Apr 30, 2004·The EMBO Journal·Zhengjian Zhang, Joseph C Reese
May 5, 2004·PLoS Biology·Hunter B FraserMichael B Eisen
May 29, 2004·Genetics·Mukund Thattai, Alexander van Oudenaarden
May 29, 2004·Science·Jonathan M Raser, Erin K O'Shea
Aug 17, 2004·Science·Nathalie Q BalabanStanislas Leibler
Sep 3, 2004·Nature·Christopher T HarbisonRichard A Young
Nov 17, 2004·Journal of Molecular Biology·Xin BiSusan Elizondo
Jun 21, 2005·The Journal of Biological Chemistry·Ian M FingermanScott D Briggs
Aug 9, 2005·Nature Genetics·Attila BecskeiAlexander van Oudenaarden
Aug 27, 2005·Cell·Dmitry K PokholokRichard A Young
Dec 22, 2005·Nature Reviews. Genetics·Alfonso Martinez Arias, Penelope Hayward
Feb 16, 2006·Molecular and Cellular Biology·Mehrdad PedramJohn P Murnane
May 23, 2006·Nature Genetics·Arren Bar-EvenNaama Barkai
Oct 25, 2006·Nature Reviews. Cancer·Anke Sparmann, Maarten van Lohuizen
Nov 4, 2006·Briefings in Functional Genomics & Proteomics·Lu Gao, David S Gross
Nov 30, 2006·Molecular Systems Biology·Alexander M TsankovJason M Casolari
Dec 26, 2006·Molecular Cell·William J BlakeJames J Collins
Apr 10, 2007·Nature Genetics·Zhanzhi HuVishwanath R Iyer
Jun 16, 2007·Science·Hédia MaamarDavid Dubnau

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BETA
ChIP-chip

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