Stochastic behavior of atrial and ventricular intrinsic cardiac neurons

Journal of Applied Physiology
M WaldmannJ A Armour

Abstract

To quantify the concurrent transduction capabilities of spatially distributed intrinsic cardiac neurons, the activities generated by atrial vs. ventricular intrinsic cardiac neurons were recorded simultaneously in 12 anesthetized dogs at baseline and during alterations in the cardiac milieu. Few (3%) identified atrial and ventricular neurons (2 of 72 characterized neurons) responded solely to regional mechanical deformation, doing so in a tightly coupled fashion (cross-correlation coefficient r = 0.63). The remaining (97%) atrial and ventricular neurons transduced multimodal stimuli to display stochastic behavior. Specifically, ventricular chemosensory inputs modified these populations such that they generated no short-term coherence among their activities (cross-correlation coefficient r = 0.21 +/- 0.07). Regional ventricular ischemia activated most atrial and ventricular neurons in a noncoupled fashion. Nicotinic activation of atrial neurons enhanced ventricular neuronal activity. Acute decentralization of the intrinsic cardiac nervous system obtunded its neuron responsiveness to cardiac sensory stimuli. Most atrial and ventricular intrinsic cardiac neurons generate concurrent stochastic activity that is predicated primarily ...Continue Reading

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Citations

Nov 18, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·David D GibbonsJeffrey L Ardell
Aug 22, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Louis-Philippe RicherJohn Andrew Armour
Jun 12, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jeffrey L ArdellJ Andrew Armour
Nov 14, 2013·Autonomic Neuroscience : Basic & Clinical·Jean C HardwickE Marie Southerland
Nov 18, 2015·The Journal of Physiology·Pradeep S RajendranKalyanam Shivkumar
Dec 17, 2008·Autonomic Neuroscience : Basic & Clinical·René CardinalJ Andrew Armour
Jun 10, 2015·Current Heart Failure Reports·Una BuckleyJeffrey L Ardell
Apr 22, 2016·The Journal of Physiology·J L ArdellI H Zucker
Oct 7, 2017·American Journal of Hypertension·Jürgen M BohlenderHans Imboden
Nov 3, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Siamak SalavatianJeffrey L Ardell
Sep 29, 2017·Frontiers in Public Health·Gernot Ernst

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