Stochastic control of metabolic pathways

Physical Biology
Andrea Rocco

Abstract

We study the effect of extrinsic noise in metabolic networks. We introduce external random fluctuations at the kinetic level, and show how these lead to a stochastic generalization of standard metabolic control analysis. While summation and connectivity theorems hold true in the presence of extrinsic noise, control coefficients incorporate its effect through an explicit dependency on the noise intensity. New elasticities and response coefficients are also defined. Accordingly, the concept of control by noise is introduced as a way of tuning the systemic behaviour of metabolisms. We argue that this framework holds for intrinsic noise too, when time-scale separation is present in the system.

References

Jun 30, 1997·Biophysical Chemistry·C K Biebricher, W C Gardiner
Feb 24, 2001·Journal of Theoretical Biology·J H Hofmeyr, H V Westerhoff
Jan 22, 2002·Physical Review Letters·E Aurell, K Sneppen
Apr 23, 2002·Nature Genetics·Ertugrul M OzbudakAlexander van Oudenaarden
Apr 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·José M G VilarStanislas Leibler
Sep 19, 2002·Proceedings of the National Academy of Sciences of the United States of America·Peter S SwainEric D Siggia
Apr 11, 2003·Nature·William J BlakeJ J Collins
Jun 6, 2003·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·O CarrilloJ M Sancho
Jul 15, 2003·Physical Review Letters·Sandip Kar, Deb Shankar Ray
Nov 15, 2003·Journal of Theoretical Biology·Mark A PeletierBoris N Kholodenko
Jan 30, 2004·Nature·Johan Paulsson
Nov 3, 2004·Nature Reviews. Genetics·Hiroaki Kitano
Nov 5, 2004·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·R KupfermanA M Stuart
Mar 26, 2005·Science·Juan M Pedraza, Alexander van Oudenaarden
Aug 9, 2005·Nature Genetics·Attila BecskeiAlexander van Oudenaarden
Dec 31, 2005·Physical Review Letters·Tianshou ZhouKazuyuki Aihara
Jan 18, 2006·Nature Chemical Biology·Brian P EnglishX Sunney Xie
Sep 22, 2006·Systems Biology·W Liebermeister, E Klipp
Oct 10, 2006·Physical Review Letters·Sorin Tănase-NicolaPieter Rein ten Wolde
Jan 16, 2007·The FEBS Journal·Luis Acerenza, Fernando Ortega
May 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Erel Levine, Terence Hwa
Jun 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Haruto IshikawaMichael D Fayer

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Citations

Sep 19, 2009·PLoS Computational Biology·Frank J BruggemanHans V Westerhoff
May 8, 2010·Mathematical Biosciences·Kyung Hyuk Kim, Herbert M Sauro
Apr 15, 2016·Journal of the Royal Society, Interface·Fei HeHans V Westerhoff
Jun 12, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Ovidiu RadulescuJosé Eduardo M Hornos
Oct 10, 2021·Cell Systems·Megan A CoomerMichael P H Stumpf

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