Stochastic morphometric model of the BALB/c mouse lung

The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology
Pierre MadlB Asgharian

Abstract

The laboratory mouse is often used as a human surrogate in aerosol inhalation studies. Morphometric data on the tracheobronchial geometry of three in situ lung casts of the Balb/c mouse lung produced by the Air Pollution Health Effects Laboratory were analyzed in terms of probability density functions and correlations among the different airway parameters. The results of this statistical analysis reveal significant differences in diameters and branching angles between major and minor progeny branching off from the same parent airway at a given airway bifurcation. Number of bronchial airways generations along a given path, expressed by the termination probability, branching angles, and daughter-to-parent diameter ratios indicate that the location of an airway with defined linear airway dimensions within the lung is more appropriately identified by its diameter (or its parent diameter) than by an assigned generation number. We, therefore, recommend classifying the mouse lung airways by their diameters and not by generation numbers, consistent with our previous analysis of the rather monopodial structure of the rat lung (Koblinger et al., J Aerosol Med 1995;8:7–19; Koblinger and Hofmann, J Aerosol Med 1995;8:21–32). Because of lac...Continue Reading

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Citations

Jan 30, 2014·American Journal of Respiratory Cell and Molecular Biology·Gregory D ScottDavid B Jacoby
Jan 9, 2016·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Ke-Yang LiuJin-Song Li
Jun 21, 2017·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Asef IslamAnthony S Wexler
Nov 28, 2019·Journal of Applied Physiology·Christian BauerReinhard R Beichel
Mar 18, 2016·Inhalation Toxicology·Renate Winkler-Heil, Werner Hofmann
Mar 15, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kurt H Albertine
Feb 9, 2021·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Michael J OldhamArkadiusz K Kuczaj
Nov 18, 2018·Respiratory Physiology & Neurobiology·Arun V KolanjiyilRuxana T Sadikot

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