Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging

Ageing Research Reviews
Alexander Fedintsev, Alexey Moskalev

Abstract

Damage accumulation in long-living macromolecules (especially extracellular matrix (ECM) proteins, nuclear pore complex (NPC) proteins, and histones) is a missing hallmark of aging. Stochastic non-enzymatic modifications of ECM trigger cellular senescence as well as many other hallmarks of aging affect organ barriers integrity and drive tissue fibrosis. The importance of it for aging makes it a key target for interventions. The most promising of them can be AGE inhibitors (chelators, O-acetyl group or transglycating activity compounds, amadorins and amadoriases), glucosepane breakers, stimulators of elastogenesis, and RAGE antagonists.

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Citations

Oct 31, 2020·International Journal of Molecular Sciences·Alessia MongelliCarlo Gaetano
Feb 11, 2021·The Journal of Investigative Dermatology·Meinhard WlaschekKarin Scharffetter-Kochanek
Dec 15, 2020·Pharmacology & Therapeutics·Jaana van GastelStuart Maudsley
May 1, 2021·International Journal of Molecular Sciences·Quentin AlleJean-Marc Lemaitre
Jun 23, 2021·Aging·Svetlana YurenevaGennady Sukhikh
Aug 19, 2021·Rejuvenation Research·Jean M Hébert

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