Stochastic properties of synaptic transmission affect the shape of spike time-dependent plasticity curves

Journal of Neurophysiology
Harel Z Shouval, Georgios Kalantzis

Abstract

Theoretical studies have shown that calcium influx through N-methyl-D-aspartate (NMDA) receptors is a sufficient signal to account for various induction protocols of bidirectional synaptic plasticity, including spike time-dependent plasticity (STDP). The STDP curves obtained by these different models exhibits a form of spike time-dependent long-term depression that occurs when a presynaptic spike precedes the postsynaptic spike (pre-post LTD). We have previously proposed that this novel form of LTD can serve as an experimental test for the validity of these models. These calcium based theoretical models assumed deterministic calcium dynamics that reflect average properties of synaptic calcium currents. In this paper, we show that taking into account the stochastic properties of synaptic transmission significantly alters the form of STDP curves and may significantly reduce the magnitude of pre-post LTD.

References

May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S M Dudek, M F Bear
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J Lisman
Feb 26, 1999·Journal of Neurophysiology·S N YangR S Zucker
Aug 18, 2000·Neural Networks : the Official Journal of the International Neural Network Society·T Kitajima, K Hara
Oct 25, 2001·Proceedings of the National Academy of Sciences of the United States of America·G C CastellaniH Z Shouval
Feb 8, 2002·Neuron·Bernardo L SabatiniKarel Svoboda
Jul 2, 2002·Journal of Neurophysiology·Uma R Karmarkar, Dean V Buonomano
Jul 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Harel Z ShouvalLeon N Cooper
Nov 9, 2002·Journal of Neurophysiology·Wu Li, Charles D Gilbert
Dec 4, 2002·Biological cybernetics·Harel Z ShouvalLeon N Cooper
Feb 20, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Thomas Nevian, Bert Sakmann
Feb 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Esther A NimchinskyKarel Svoboda
Mar 5, 2004·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Luk C YeungHarel Z Shouval

❮ Previous
Next ❯

Citations

May 12, 2006·International Journal of Neural Systems·Mathilde BadoualAlain Destexhe
Nov 26, 2008·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Rebekah CorlewBenjamin D Philpot
Dec 7, 2007·PLoS Computational Biology·Michael Graupner, Nicolas Brunel
Dec 4, 2009·PloS One·Georgios Kalantzis, Harel Z Shouval
Apr 21, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vanessa A BenderDaniel E Feldman
Aug 3, 2012·The Journal of Chemical Physics·Animesh AgarwalHarel Z Shouval
Jun 25, 2015·Frontiers in Cellular Neuroscience·Vincent DelattreEilif B Muller
May 6, 2009·Computational Biology and Chemistry·Georgios Kalantzis
May 13, 2006·Biological cybernetics·Neel T ShahHarel Z Shouval
Feb 1, 2007·Journal of Computational Neuroscience·Minija TamosiunaiteFlorentin Wörgötter
Jan 19, 2008·Journal of Computational Neuroscience·Shigeru Kubota, Tatsuo Kitajima
Dec 31, 2004·Journal of Neurophysiology·Jonathan E RubinCarson C Chow
Dec 2, 2005·Journal of Neurophysiology·Robert C FroemkeYang Dan
Feb 3, 2007·Journal of Neurophysiology·Richard C GerkinGuo-Qiang Bi
May 23, 2012·Journal of Computational Neuroscience·Daniel Bush, Yaochu Jin
Sep 22, 2007·Neural Computation·Joseph M BraderStefano Fusi
Jun 5, 2016·Journal of Computational Neuroscience·M T WilsonJ N J Reynolds
Jul 19, 2018·Frontiers in Computational Neuroscience·Alexandre FoncelleLaurent Venance
Jan 26, 2020·Journal of Computational Neuroscience·Akke Mats Houben, Matthias S Keil
Apr 27, 2019·Biophysical Journal·Takehiro TottoriShinya Kuroda
May 24, 2008·Neuron·Thomas M Newpher, Michael D Ehlers

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Harel Z ShouvalLeon N Cooper
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Esther A NimchinskyKarel Svoboda
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Gayle M Wittenberg, Samuel S-H Wang
© 2021 Meta ULC. All rights reserved