Stochasticity of the step size in the force generating process due to a single myosin molecule

Bulletin of Mathematical Biology
Yuki Kagawa, Yoshimi Tsuchiya

Abstract

We formulate a motional model on the basis of an experimental optical trapping system which reveals the single molecular events of the force generation due to actin and myosin, and we discuss the origin of the dispersion of the displacements of the beads bound to the actin filament. In some experimental data sets, this dispersion is larger than that presumed from the model under the condition that the thermal agitation is the only source of the fluctuation. Thus, other fluctuating elements besides that due to thermal agitation are supposed to cause the dispersion. A possible fluctuating element is the step size itself. We discuss this possibility and estimate the fluctuation in step size using two reported experimental data sets.

References

Nov 9, 1995·Nature·J E MolloyD C White
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·H KojimaT Yanagida
Feb 1, 1997·Current Biology : CB·K C Holmes
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·A D MehtaJ A Spudich
Aug 6, 1999·Biochemistry·S Highsmith

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Citations

Feb 19, 2009·Asia-Pacific Journal of Public Health·Keiko NakamotoAkira Tanaka
Mar 16, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Yuki Kagawa

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