Stockpiling Ventilators for Influenza Pandemics

Emerging Infectious Diseases
Hsin-Chan HuangLauren Ancel Meyers

Abstract

In preparing for influenza pandemics, public health agencies stockpile critical medical resources. Determining appropriate quantities and locations for such resources can be challenging, given the considerable uncertainty in the timing and severity of future pandemics. We introduce a method for optimizing stockpiles of mechanical ventilators, which are critical for treating hospitalized influenza patients in respiratory failure. As a case study, we consider the US state of Texas during mild, moderate, and severe pandemics. Optimal allocations prioritize local over central storage, even though the latter can be deployed adaptively, on the basis of real-time needs. This prioritization stems from high geographic correlations and the slightly lower treatment success assumed for centrally stockpiled ventilators. We developed our model and analysis in collaboration with academic researchers and a state public health agency and incorporated it into a Web-based decision-support tool for pandemic preparedness and response.

References

Nov 14, 2006·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Xinzhi ZhangPascale M Wortley
May 18, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·David StiffStasa Veroukis
Jan 1, 2009·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Paul SmetaninFrank Plummer
Dec 25, 2012·Emerging Infectious Diseases·Carrie ReedDaniel B Jernigan
Mar 26, 2013·Annals of Emergency Medicine·Justin W TimbieArthur L Kellermann
Apr 17, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Martin I MeltzerLisa M Koonin
Oct 10, 2015·Disaster Medicine and Public Health Preparedness·Adebola AjaoMartin I Meltzer

❮ Previous
Next ❯

Citations

May 23, 2019·Current Opinion in Infectious Diseases·Andrew Pavia
Sep 17, 2019·PLoS Computational Biology·Srinivasan VenkatramananAnil Vullikanti
Aug 25, 2020·Medical Devices & Sensors·Aditya VasanJames Friend
Aug 25, 2020·HardwareX·Aliaksei PetsiukJoshua M Pearce
Feb 17, 2021·Health Care Management Science·Dimitris BertsimasCynthia Zeng
Sep 1, 2021·Disaster Medicine and Public Health Preparedness·Yang LiSilvia M Trigoso
Aug 31, 2021·SN Computer Science·Jiajun Xu, Suvrajeet Sen
Dec 21, 2021·Anesthesia and Analgesia·Micha Sam Brickman RaredonLaura E Niklason

❮ Previous
Next ❯

Software Mentioned

ILINet
FluSurge
Google Flu Trends

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Emerging Infectious Diseases
Kathleen F GensheimerRaymond A Strikas
MedGenMed : Medscape General Medicine
Harvey V Fineberg
© 2022 Meta ULC. All rights reserved