Stone formation in genetic hypercalciuric rats

Kidney International
David A BushinskyF L Coe

Abstract

Our genetic hypercalciuric (GH) rats have been selected and inbred for 29 generations to maximize urine calcium (UCa) excretion compared to identical gender controls (Ctl). To determine the effect of the increased UCa on urinary supersaturation and stone formation, we pair fed 15 GH and 15 Ctl rats a standard 1.2% calcium diet for 18 weeks, measured urine supersaturation every two weeks, and examined the urinary tract of 1/3 of the rats for the presence of stones every six weeks. Any stones formed were studied by SEM, X-ray and electron diffraction and X-ray microanalysis. Over the entire study UCa was increased in the GH compared to Ctl, resulting in greater supersaturation with respect to calcium hydrogen phosphate (CaHPO4) at all times and calcium oxalate (CaOx) at most times. There was a progressive increase in the incidence of stone formation in GH rats with one of five rats having stones at six weeks, three of five with stones at 12 weeks and five of five with stones at 18 weeks. There were no stones formed in Ctl rats. SEM reveals discrete stones and not nephrocalcinosis. X-ray and electron diffraction and X-ray microanalysis reveal the stones to be poorly crystalline apatite which is a solid phase of calcium and phospha...Continue Reading

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Citations

Jan 1, 1997·World Journal of Urology·S R Khan
Dec 19, 2012·Calcified Tissue International·Nancy S Krieger, David A Bushinsky
Jan 27, 2006·Urological Research·John P Kavanagh
Jan 20, 1999·Kidney International·D A BushinskyN S Krieger
Jan 5, 2000·Kidney International·S J ScheinmanR V Thakker
Feb 19, 2002·Kidney International·David A BushinskyFredric L Coe
Sep 24, 1999·Current Opinion in Nephrology and Hypertension·D A Bushinsky
Jun 16, 2006·Current Opinion in Nephrology and Hypertension·Shaochun Bai, Murray J Favus
Jun 16, 2006·Current Opinion in Nephrology and Hypertension·David A BushinskyKeith Nehrke
Apr 3, 2012·The Journal of Clinical Endocrinology and Metabolism·Khashayar SakhaeeBridget Sinnott
Apr 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·F L Coe, J H Parks
Apr 17, 2009·Journal of the American Society of Nephrology : JASN·John R AsplinDavid A Bushinsky
Apr 10, 2014·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Jennifer N NiemuthMichael K Stoskopf
Jan 25, 2013·American Journal of Physiology. Renal Physiology·Kevin K FrickDavid A Bushinsky
Sep 8, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D A Bushinsky
May 1, 1997·Kidney International·S TsuruokaG J Schwartz
Dec 20, 2008·Advances in Chronic Kidney Disease·Khashayar Sakhaee
Mar 5, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Alexander J KarnauskasMurray J Favus
Feb 26, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·David A BushinskyMarc Grynpas
Apr 17, 2002·The Journal of Urology·Jennifer M KinderFredric L Coe
Mar 6, 2003·The Journal of Clinical Investigation·David A Bushinsky
Jan 14, 2005·Journal of the American Society of Nephrology : JASN·David A Bushinsky, John R Asplin
Mar 25, 2005·Journal of the American Society of Nephrology : JASN·Jim J YaoMurray J Favus
Apr 10, 2015·Journal of the American Society of Nephrology : JASN·Nancy S KriegerDavid A Bushinsky
Apr 14, 2006·Journal of the American Society of Nephrology : JASN·Richard R HoopesSteven J Scheinman
Feb 28, 2014·American Journal of Physiology. Renal Physiology·Kevin K FrickDavid A Bushinsky
Jun 8, 2015·Current Opinion in Nephrology and Hypertension·Kevin K FrickDavid A Bushinsky
Feb 27, 2009·American Journal of Physiology. Renal Physiology·Yan Li, Kenneth E McMartin
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Mar 23, 2018·Nutrients·Emmanuel Letavernier, Michel Daudon
Mar 28, 2019·Urolithiasis·Doyoung KimJohn R Asplin
Mar 7, 2006·Current Rheumatology Reports·Scott E LiebmanDavid A Bushinsky
Aug 9, 2013·American Journal of Physiology. Renal Physiology·Kevin K FrickDavid A Bushinsky

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