Stool antigen tests for the detection of Helicobacter pylori in children

Diagnostic Microbiology and Infectious Disease
Kaija-Leena KolhoHilpi Rautelin

Abstract

Stool specimens from 102 children (median age = 6.0 years; Helicobacter pylori in biopsy specimens, n = 43) were tested for H. pylori with the monoclonal antibody-based enzyme immunoassay HpStar. In 28 cases, the specimen was obtained with a rectal cotton swab during endoscopy. The sensitivity and specificity of the HpStar were 0.95 and 0.90, respectively, as compared with biopsy-based methods. The rectal cotton swab specimen gave accurate results in 24 of the 28 cases. Storage of specimens for 1, 3, or 7 days (n = 6) had a minor effect on the results, but one specimen's originally positive value on borderline turned negative when it was kept in room temperature. Forty-eight specimens were tested in parallel with all 3 tests used: HpStar, Premium Platinum HpSA, and the rapid test ImmunoCardSTAT! The accuracy rates of the tests were 98% for the HpSA and HpStar and 96% for the ImmunoCardSTAT! The performance of the stool antigen tests was excellent in young children.

References

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Citations

Jun 8, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A SchwarzerS Koletzko
Nov 6, 2014·Jundishapur Journal of Microbiology·Tahereh FalsafiZahra Landarani
Jul 21, 2009·European Journal of Pediatrics·Jeannette GuarnerSibylle Koletzko
Mar 19, 2014·Clinics and Research in Hepatology and Gastroenterology·Xiaoying ZhouGuoxin Zhang
Mar 16, 2018·The Cochrane Database of Systematic Reviews·Lawrence Mj BestKurinchi Selvan Gurusamy
Oct 11, 2007·Helicobacter·Meltem Yalinay CirakFrancis Mégraud
Oct 11, 2007·Helicobacter·Gabor Veres, Ender Pehlivanoglu
Sep 22, 2010·Scandinavian Journal of Clinical and Laboratory Investigation·Hilpi RautelinKaija-Leena Kolho

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