Stop Fitan: antispasmodic effect of natural extract of chestnut wood in guinea pig ileum and proximal colon smooth muscle

Journal of Medicinal Food
Roberta BudriesiAlberto Chiarini

Abstract

Abstract Stop Fitan® [manufactured by Demar Snc, Cesena (FC), Italy, on behalf of Geosilva, Cesena] is a dietary supplement proposed as a co-adjuvant in the therapy of diarrhea. It is based on the bioactive purified natural extract of chestnut (Castanea sativa) wood and Saccharomyces boulardii, a nonpathogenic yeast strain that has been used for treatment and prevention of diarrhea. The effects of Stop Fitan and the purified natural extract of chestnut wood were assessed in vitro using guinea pig ileum and proximal colon tissues. In order to explain their effects on intestinal smooth muscle contraction, a series of pathways implicated in intestinal motility have been investigated. In particular, the antispasmodic effect of natural extract of chestnut wood, containing hydrolyzable tannins, was tested against the spasmodic effects induced by carbachol, histamine, potassium chloride, and barium chloride in guinea pig ileum and by carbachol or serotonin in guinea pig proximal colon. The data show that natural extract of chestnut wood exerts spasmolytic effects in ileum and proximal colon, by a mechanism perhaps involving unspecific cellular pathways. These findings, taken together with the antibacterial, antiviral, and antispasmodi...Continue Reading

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Citations

Mar 28, 2013·Oxidative Medicine and Cellular Longevity·Alberto ChiariniSilvana Hrelia
Jan 13, 2015·Cancer Chemotherapy and Pharmacology·Priscilla F C JustinoPedro Marcos Gomes Soares
Jul 26, 2016·Frontiers in Pharmacology·Muhammad U AshrafSyed N A Bukhari
Apr 20, 2017·Journal of Medicinal Food·Matteo MicucciRoberta Budriesi
Feb 13, 2020·Journal of Animal Physiology and Animal Nutrition·Jennifer L MacNicolWendy Pearson
Aug 1, 2018·Veterinary Research·Hyun LillehojCyril G Gay
May 10, 2017·BMC Complementary and Alternative Medicine·Monia LenziPatrizia Hrelia
Apr 4, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Hafiz Muhammad Abdur RahmanImran Imran
Dec 10, 2020·Phytotherapy Research : PTR·Matteo MicucciAndrea Angeletti
May 24, 2019·Journal of Agricultural and Food Chemistry·Silvia MolinoMariano Enrique Fernandez Miyakawa

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