Stop GnRH-Agonist Combined With Multiple-Dose GnRH-Antagonist Protocol for Patients With "Genuine" Poor Response Undergoing Controlled Ovarian Hyperstimulation for IVF.

Frontiers in Endocrinology
Raoul OrvietoRavit Nahum

Abstract

Objective: To examine whether the Stop GnRH-agonist combined with multiple-dose GnRH-antagonist protocol may improve conventional IVF/intracytoplasmic sperm injection (ICSI) cycle in poor ovarian response (POR) patients. Design: Cohort historical, proof of concept study. Setting: Tertiary, University affiliated Medical Center. Patient(s): Thirty POR patients, defined according to the Bologna criteria, who underwent a subsequent Stop GnRH-agonist combined with multiple-dose GnRH-antagonist controlled ovarian hyperstimulation (COH) protocol, within 3 months of the previous failed conventional IVF/ICSI cycle, were included. For the purposes of this study, we eliminated a bias in this selection by including only "genuine" poor responder patients, defined as those who yielded up to 3 oocytes following COH with a minimal gonadotropin daily dose of 300 IU. Main Outcome Measure(s): Number of oocytes retrieved, number of top-quality embryos, COH variables. Result(s): The Stop GnRH-agonist combined with multiple-dose GnRH-antagonist COH protocol revealed significantly higher numbers of follicles >13 mm on the day of hCG administration, higher numbers of oocytes retrieved, and top-quality embryos (TQE) with an acceptable clinical pregnanc...Continue Reading

References

Dec 1, 1994·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Z Ben-RafaelD Feldberg
Apr 9, 2002·Fertility and Sterility·Mohamed Farouk M Mitwally, Robert F Casper
Jul 21, 2007·Human Reproduction·Søren ZiebeUNKNOWN MERIT (Menotrophin vs Recombinant FSH in vitro Fertilisation Trial) Group
Sep 18, 2007·Human Reproduction·J A HuirneC B Lambalk
Apr 21, 2011·Human Reproduction·A P FerrarettiUNKNOWN ESHRE working group on Poor Ovarian Response Definition
Aug 13, 2011·The Cochrane Database of Systematic Reviews·Abha MaheshwariSiladitya Bhattacharya
Nov 29, 2012·Reproductive Biomedicine Online·Raoul Orvieto, Pasquale Patrizio
Feb 1, 2017·Human Reproduction·P HumaidanUNKNOWN ESPART Study Investigators‡
Dec 11, 2017·Reproductive Biomedicine Online·Kelly J GondaRichard P Marrs
Feb 28, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Jigal HaasRaoul Orvieto

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