Stopping nucleos(t)ide analogue treatment in Caucasian hepatitis B patients after HBeAg seroconversion is associated with high relapse rates and fatal outcomes

Alimentary Pharmacology & Therapeutics
S Van HeesBelgian NA Stop Study Group

Abstract

Stopping nucleos(t)ide analogues (NA) after hepatitis B e antigen (HBeAg) seroconversion is associated with high relapse rates in Asian patients, but data in Caucasian cohorts are scarce. Clinical course, outcomes and immunological aspects of chronic hepatitis B infections differ substantially between distinct ethnicities. The aim of this study was to determine relapse rates, factors predicting relapse and clinical outcomes after nucleos(t)ide analogue cessation in a large, predominantly Caucasian cohort of chronic hepatitis B patients with nucleos(t)ide analogue-induced HBeAg seroconversion. This is a nationwide observational cohort study including HBeAg positive, mono-infected chronic hepatitis B patients with nucleos(t)ide analogue-induced HBeAg seroconversion from 18 centres in Belgium. A total of 98 patients with nucleo(s)tide analogue-induced HBeAg seroconversion were included in the study. Of the 62 patients who stopped treatment after a median consolidation treatment of 8 months, 30 relapsed. Higher gamma-glutamyl transferase levels at both treatment initiation (HR 1.004; P = 0.001 per unit increment) and HBeAg seroconversion (HR 1.006; P = 0.013 per unit increment) were associated with an increased risk of clinically s...Continue Reading

References

May 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yao-Shih HsuYun-Fan Liaw
Dec 4, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pierre BedossaValerie Paradis
Jan 30, 2004·Journal of Gastroenterology and Hepatology·Ivonette S S SilvaAntonio E B Silva
Aug 22, 2008·Journal of Hepatology·Annika KauChristoph Sarrazin
Sep 19, 2008·Journal of Virology·Anthony Tanoto TanAntonio Bertoletti
Oct 4, 2008·The New England Journal of Medicine·Jules L Dienstag
Feb 14, 2009·Journal of Gastroenterology·Chenyan ZhaoYouchun Wang
Jun 16, 2011·Alimentary Pharmacology & Therapeutics·Y LiangH L-Y Chan
Mar 20, 2012·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver, UNKNOWN European Organisation For Research And Treatment Of Cancer
Mar 23, 2012·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver
Dec 22, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·James E Everhart, Elizabeth C Wright
Nov 14, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Edith M KoehlerHarry L A Janssen
Dec 4, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D HeM Ding
Jan 18, 2015·Journal of Hepatology·George V PapatheodoridisPietro Lampertico
Mar 11, 2015·Alimentary Pharmacology & Therapeutics·H ChiH L A Janssen
Mar 27, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Thomas VanwolleghemAndre Boonstra
Sep 18, 2015·World Journal of Gastroenterology : WJG·Rui HuangChao Wu
Nov 3, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Yuan-Wang QiuJian-He Gan
Nov 14, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Norah A TerraultUNKNOWN American Association for the Study of Liver Diseases
Dec 1, 2015·The American Journal of Gastroenterology·Ju Dong YangUNKNOWN Africa Network for Gastrointestinal and Liver Diseases
Jan 5, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Jiannis Vlachogiannakos, George V Papatheodoridis
Apr 23, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·George PapatheodoridisJörg Petersen
Jun 1, 2016·Journal of Immunology Research·Li WangKai Wang
Oct 13, 2016·World Journal of Gastroenterology : WJG·Stijn Van HeesThomas Vanwolleghem
Jan 5, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Guo-Feng ChenGeorge Lau
Apr 22, 2017·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, UNKNOWN European Association for the Study of the Liver
Jun 18, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·George V PapatheodoridisPietro Lampertico

❮ Previous
Next ❯

Citations

Jan 10, 2019·Expert Review of Clinical Pharmacology·Lung-Yi MakMan-Fung Yuen
Dec 18, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Grace L-H WongVincent W-S Wong
May 10, 2018·World Journal of Gastroenterology : WJG·Elia Moreno-CuberoJuan Ramón Larrubia
Mar 28, 2021·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tao LiLei Wang
Jun 29, 2021·Seminars in Liver Disease·Wen-Juei Jeng, Yun-Fan Liaw
Jul 24, 2021·Hepatology International·Jia-Horng KaoMan-Fung Yuen
Sep 1, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Yao-Chun HsuChih-Lung Hung
Feb 15, 2020·The Lancet. Gastroenterology & Hepatology·Marc G GhanyHarry L A Janssen
Sep 14, 2021·Journal of Viral Hepatitis·Hannah S J ChoiHarry L A Janssen
Dec 1, 2021·United European Gastroenterology Journal·Arno Furquim d'AlmeidaThomas Vanwolleghem

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

SPSS

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.