Storage of platelet concentrates from pooled buffy coats made of fresh and overnight-stored whole blood processed on the novel Atreus 2C+ system: in vitro study

Transfusion
P SandgrenH Gulliksson

Abstract

The Atreus 2C+ system (Gambro BCT) automatically separates whole blood (WB) into buffy coat (BC), red blood cells (RBC), and plasma and transfers the components into separate containers. After processing with the Atreus, 4 to 6 BC units can be pooled and processed into leukoreduced platelets (PLTs) by use of the automated OrbiSac BC system (Gambro BCT). The aim of our in vitro study was to investigate the effects of holding either WB or BC overnight before preparation of PLTs by use of the Atreus 2C+ system for BC preparation. A standard routine procedure involving conventional blood containers for the preparation of BC combined with the OrbiSac process (top-and-top system; Terumo) was used as a reference. WB was either processed within 8 hours after collection ("fresh blood") or stored overnight before processing. WB units were separated into BC, RBC, and plasma units and transferred into individual containers. Either the BC or the WB units rested overnight at 22 +/- 2 degrees C. Six ABO-identical BCs, obtained from either fresh or overnight-stored WB, were pooled and processed with the OrbiSac BC system to obtain leukoreduced PLTs. In total, 20 Atreus and 10 reference (leukoreduced PLTs) samples were analyzed for various in v...Continue Reading

References

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Citations

Sep 1, 2009·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·R N I Pietersz
May 19, 2009·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·R TardivelH Isola
Oct 17, 2008·Journal of Dermatological Science·Norito Katoh
Sep 9, 2008·Transfusion·Stephen ThomasRebecca Cardigan
Nov 3, 2011·Transfusion·Nahreen TynngårdGösta Berlin
Jan 28, 2011·Transfusion·M J Dijkstra-TiekstraUNKNOWN Biomedical Excellence for Safer Transfusion Collaborative
Jun 15, 2011·Vox Sanguinis·S Panzer, P Jilma
Nov 30, 2014·Transfusion Medicine Reviews·Pieter F van der Meer, Dirk de Korte
Dec 3, 2020·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Shashank OjhaMinal Poojary

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