Store-depletion and hyperforin activate distinct types of Ca(2+)-conducting channels in cortical neurons

Cell Calcium
Julien GibonAlexandre Bouron

Abstract

Cortical neurons embryos (E13) from murine brain have a wide diversity of plasma membrane Ca(2+)-conducting channels. For instance, they express several types of transient receptor potential channels of C-type (TRPC) and hyperforin, a potent TRPC6-channel activator, controls the activity of TRPC6-like channels. In addition, E13 cortical neurons possess plasma membrane channels activated in response to the depletion of internal Ca(2+) pools. Since some TRPC channels seem to be involved in the activity of store-depletion-activated channels, we investigated whether hyperforin and the depletion of the Ca(2+) stores control similar or distinct Ca(2+) routes. Calcium imaging experiments performed with the fluorescent Ca(2+) indicator Fluo-4 showed that the TRPC3 channel blocker Pyr3 potently inhibits with an IC(50) of 0.5microM the entry of Ca(2+) triggered in response to the thapsigargin-dependent depletion of the Ca(2+) stores. On the other hand, Pyr3 does not block the hyperforin-sensitive Ca(2+) entry. In contrast to the hyperforin responses, the Ca(2+) entry through the store-depletion-activated channels is down-regulated by the competitive tyrosine kinase inhibitors genistein and PP2. In addition, the immunosuppressant FK506, k...Continue Reading

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Citations

May 28, 2011·Journal of Cellular Physiology·Sanjay KumarAlexander G Obukhov
Dec 17, 2014·Journal of Neuroscience Research·Eric Zhang, Ping Liao
Aug 5, 2015·Biochimica Et Biophysica Acta·Esther LopezPedro C Redondo
Aug 26, 2011·Biochimica Et Biophysica Acta·Julien GibonAlexandre Bouron
Dec 12, 2012·Biochimica Et Biophysica Acta·Esther LópezPedro C Redondo
Feb 10, 2010·Cell·Henry G S Martin, Yu Tian Wang
Jun 15, 2021·Frontiers in Pharmacology·Xiaojing LiangWeidong Han
Feb 21, 2018·Chemical Reviews·Xing-Wei YangGang Xu

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