Store-operated Ca2+ channels in prostate cancer epithelial cells: function, regulation, and role in carcinogenesis

Cell Calcium
F Vanden AbeeleN Prevarskaya

Abstract

Ca2+ homeostasis mechanisms, in which the Ca2+ entry pathways play a key role, are critically involved in both normal function and cancerous transformation of prostate epithelial cells. Here, using the lymph node carcinoma of the prostate (LNCaP) cell line as a major experimental model, we characterize prostate-specific store-operated Ca2+ channels (SOCs)--a primary Ca2+ entry pathway for non-excitable cells--for the first time. We show that prostate-specific SOCs share major store-dependent, kinetic, permeation, inwardly rectifying, and pharmacological (including dual, potentiation/inhibition concentration-dependent sensitivity to 2-APB) properties with "classical" Ca2+ release-activated Ca2+ channels (CRAC), but have a higher single channel conductance (3.2 and 12pS in Ca2+- and Na+-permeable modes, respectively). They are subject to feedback inhibition via Ca2+-dependent PKC, CaMK-II and CaM regulatory pathways and are functionally dependent on caveolae integrity. Caveolae also provide a scaffold for spatial co-localization of SOCs with volume-regulated anion channels (VRAC) and their Ca2+-mediated interaction. The TRPC1 and TRPV6 members of the transient receptor potential (TRP) channel family are the most likely molecular ...Continue Reading

References

Feb 14, 1992·Analytical Biochemistry·S P Brooks, K B Storey
Feb 1, 1986·Cell Calcium·J W Putney
Jan 1, 1981·The Journal of Physiology·O A KrishtalY A Shakhovalov
Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·P D WesC Montell
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·A B Parekh, R Penner
Jul 1, 1994·Biophysical Journal·A Lückhoff, D E Clapham
Jun 1, 1993·The Journal of Physiology·M Hoth, R Penner
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A Zweifach, R S Lewis
Jul 1, 1996·Journal of the American Society of Nephrology : JASN·P MenèG A Cinotti
Nov 5, 1997·Biochemical and Biophysical Research Communications·D J McConkey, S Orrenius
Oct 28, 1998·Nature·M J BerridgeP Lipp
Mar 13, 1999·The Journal of Biological Chemistry·S JayadevE Murphy
Jun 11, 1999·The Urologic Clinics of North America·J T Isaacs
Oct 12, 1999·The Journal of Physiology·D TrouetJ Eggermont
Jan 6, 2000·Japanese Journal of Pharmacology·Y M Leung, C Y Kwan
Apr 15, 2000·The Journal of Biological Chemistry·T P LockwichI S Ambudkar
Oct 24, 2000·The Journal of Biological Chemistry·F J BraunJ W Putney
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·B A NiemeyerC Trost
Mar 30, 2001·The Journal of Biological Chemistry·U WissenbachV Flockerzi
Apr 24, 2001·Pflügers Archiv : European journal of physiology·S O ZhuravlevaY M Shuba
May 16, 2001·The Journal of Biological Chemistry·R MaS C Sansom
Jun 5, 2001·Nature Reviews. Neuroscience·D E ClaphamC Strübing
Jun 13, 2001·Biochemical and Biophysical Research Communications·J B PengM R Freeman
Sep 12, 2001·Advanced Drug Delivery Reviews·J CouetM C Drolet
Nov 1, 2001·The Journal of Biological Chemistry·T VoetsB Nilius
Dec 18, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Loïc LemonnierRoman Skryma

❮ Previous
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Citations

Dec 20, 2005·The Journal of Membrane Biology·R Schreiber
Jan 30, 2010·Pflügers Archiv : European journal of physiology·Stefan Feske
Nov 6, 2010·Pflügers Archiv : European journal of physiology·Maria ValeroFelix Viana
Jun 3, 2008·Cell Biology and Toxicology·Wade T BarrancoCurtis D Eckhert
Apr 12, 2005·Cell Calcium·Piotr Bregestovski, Nicholas Spitzer
Aug 31, 2012·The Journal of Biological Chemistry·Rainer SchindlChristoph Romanin
Mar 23, 2011·Cold Spring Harbor Perspectives in Biology·Geneviève DupontJames W Putney
Jul 29, 2004·Science's STKE : Signal Transduction Knowledge Environment·Victoria M Bolotina
Dec 20, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Isabelle Dhennin-DuthilleHalima Ouadid-Ahidouch
Apr 1, 2009·Therapeutic Advances in Urology·Massimo LazzeriMassimo Porena
Feb 25, 2011·PloS One·V'yacheslav Lehen'kyiNatalia Prevarskaya
Feb 15, 2012·The Journal of Physiology·V'yacheslav Lehen'kyiNatalia Prevarskaya
May 30, 2013·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Wenjun LiFei Zou
Jan 30, 2013·Cell Calcium·Stephan M Huber
Dec 8, 2014·Science China. Life Sciences·Zui Pan, JianJie Ma
Oct 13, 2015·Biochimica Et Biophysica Acta·Isaac Jardin, Juan A Rosado
Mar 30, 2010·The Veterinary Journal·Piper L NelsonHenrique Cheng
Mar 14, 2007·Cell Calcium·Indu S AmbudkarKwong Tai Cheng
Apr 18, 2009·Basic & Clinical Pharmacology & Toxicology·Jong-Khing HuangChung-Ren Jan
Jun 27, 2006·Journal of Cellular and Molecular Medicine·E E DanielW J Cho
Sep 1, 2004·Biochemical and Biophysical Research Communications·Natalia PrevarskayaYaroslav Shuba
Jul 21, 2004·Cell Calcium·Emil C Toescu
Dec 17, 2005·Cell Calcium·Eva C SchwarzMarkus Hoth
Mar 31, 2016·International Journal of Molecular Sciences·Xiaolei LiHongli Sun
Aug 16, 2015·Cellular Signalling·Mauro Cunha Xavier PintoRodrigo R Resende
Sep 3, 2008·Journal of Zhejiang University. Science. B·Rui-wei Guo, Lan Huang
Aug 1, 2012·Biochemical and Biophysical Research Communications·Sarah E KobylewskiCurtis D Eckhert
Jul 10, 2007·Biochimica Et Biophysica Acta·Natalia PrevarskayaGreg Barritt
Aug 3, 2004·Journal of Pharmacological Sciences·Toyohisa HananoRyuji Inoue
Jun 2, 2016·Journal of Korean Medical Science·Sayamaa LkhagvadorjMinseob Eom
Sep 5, 2006·Cell Calcium·Benjamin BeckNatalia Prevarskaya
May 1, 2010·Expert Review of Clinical Pharmacology·Ivan BogeskiChristine Peinelt
May 5, 2007·Cell Death and Differentiation·N PrevarskayaY Shuba

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