Stores, Channels, Glue, and Trees: Active Glial and Active Dendritic Physiology.

Molecular Neurobiology
Sufyan Ashhad, Rishikesh Narayanan

Abstract

Glial cells and neuronal dendrites were historically assumed to be passive structures that play only supportive physiological roles, with no active contribution to information processing in the central nervous system. Research spanning the past few decades has clearly established this assumption to be far from physiological realities. Whereas the discovery of active channel conductances and their localized plasticity was the turning point for dendritic structures, the demonstration that glial cells release transmitter molecules and communicate across the neuroglia syncytium through calcium wave propagation constituted path-breaking discoveries for glial cell physiology. An additional commonality between these two structures is the ability of calcium stores within their endoplasmic reticulum (ER) to support active propagation of calcium waves, which play crucial roles in the spatiotemporal integration of information within and across cells. Although there have been several demonstrations of regulatory roles of glial cells and dendritic structures in achieving common physiological goals such as information propagation and adaptability through plasticity, studies assessing physiological interactions between these two active struct...Continue Reading

References

Nov 1, 1977·The Journal of General Physiology·F Bezanilla, C M Armstrong
Oct 1, 1992·Journal of Neurophysiology·V Lev-RamW N Ross
Nov 1, 1990·Trends in Pharmacological Sciences·D Nicholls, D Attwell
Oct 1, 1988·Trends in Neurosciences·R W TsienA P Fox
Sep 21, 1989·Nature·M J Berridge, R F Irvine
Nov 1, 1972·The Journal of General Physiology·F Bezanilla, C M Armstrong
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·M TerasakiT S Reese
Jun 30, 1994·Nature·V ParpuraP G Haydon
Jun 1, 1994·Glia·Y Shao, K D McCarthy
Jun 1, 1993·Pflügers Archiv : European journal of physiology·G J StuartB Sakmann
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·C DemerensC Lubetzki
Jan 1, 1996·Annual Review of Neuroscience·D JohnstonB R Cristie
Aug 1, 1996·Trends in Neurosciences·A Verkhratsky, H Kettenmann
Dec 9, 1997·The Journal of Pathology·S H BarskyS M Love
Aug 11, 1998·Neuron·M J Berridge
Sep 30, 1998·The European Journal of Neuroscience·A AraqueP G Haydon
Jan 23, 1999·Journal of Neurophysiology·D A Hoffman, D Johnston
Apr 10, 1999·Nature Neuroscience·J KangM Nedergaard
May 14, 1999·Trends in Neurosciences·A AraqueP G Haydon

❮ Previous
Next ❯

Citations

Jul 14, 2019·Hippocampus·Rahul K Rathour, Rishikesh Narayanan
Dec 5, 2019·Journal of Computational Neuroscience·Jhunlyn LorenzoSabir Jacquir
Sep 29, 2020·Physical Review Research·Pavithraa Seenivasan, Rishikesh Narayanan
May 18, 2021·Frontiers in Cellular Neuroscience·Ji-In Vivien ChoiRobert Paul Malchow
Aug 21, 2021·Current Opinion in Neurobiology·Poonam Mishra, Rishikesh Narayanan
Nov 3, 2021·Physiological Reviews·Carolin Wichmann, Thomas Kuner

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques
super resolution microscopy

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.