PMID: 9445031Jan 28, 1998Paper

STP and Tip are essential for herpesvirus saimiri oncogenicity

Journal of Virology
S M DuboiseJ U Jung

Abstract

Mutant forms of herpesvirus saimiri (HVS) subgroup C strain 488 with deletions in either STP-C488 or Tip were constructed. The transforming potentials of the HVS mutants were tested in cell culture and in common marmosets. Parental HVS subgroup C strain 488 immortalized common marmoset T lymphocytes in vitro to interleukin-2-independent growth, but neither of the deletion mutants produced such growth transformation. Wild-type HVS produced fatal lymphoma within 19 to 20 days of experimental infection of common marmosets, while HVS deltaSTP-C488 and HVS deltaTip were nononcogenic. Virus was repeatedly isolated from the peripheral blood of marmosets infected with mutant virus for more than 5 months. These results demonstrate that STP-C488 and Tip are not required for replication or persistence, but each is essential for transformation in cell culture and for lymphoma induction in common marmosets.

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Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·S M DuboiseJ U Jung

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Citations

Aug 26, 1998·Journal of the National Cancer Institute. Monographs·F NeipelB Fleckenstein
Feb 13, 2001·The Journal of General Virology·S HörB Biesinger
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