Strabismus and the Oculomotor System: Insights from Macaque Models

Annual Review of Vision Science
Vallabh E Das

Abstract

Disrupting binocular vision in infancy leads to strabismus and oftentimes to a variety of associated visual sensory deficits and oculomotor abnormalities. Investigation of this disorder has been aided by the development of various animal models, each of which has advantages and disadvantages. In comparison to studies of binocular visual responses in cortical structures, investigations of neural oculomotor structures that mediate the misalignment and abnormalities of eye movements have been more recent, and these studies have shown that different brain areas are intimately involved in driving several aspects of the strabismic condition, including horizontal misalignment, dissociated deviations, A and V patterns of strabismus, disconjugate eye movements, nystagmus, and fixation switch. The responses of cells in visual and oculomotor areas that potentially drive the sensory deficits and also eye alignment and eye movement abnormalities follow a general theme of disrupted calibration, lower sensitivity, and poorer specificity compared with the normally developed visual oculomotor system.

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Citations

Apr 14, 2017·Journal of Neurophysiology·Mark M G WaltonKristina Tarczy-Hornoch
May 29, 2018·Journal of Pediatric Ophthalmology and Strabismus·Daniel L AdamsJonathan C Horton
Oct 17, 2018·Investigative Ophthalmology & Visual Science·Mythri PullelaVallabh E Das
Aug 16, 2018·Journal of Neurophysiology·Adam PallusMichael Mustari
Dec 1, 2017·Neurology·João LemosCristina Januário
Apr 14, 2020·Investigative Ophthalmology & Visual Science·Apoorva KarsoliaVallabh E Das
May 24, 2020·Investigative Ophthalmology & Visual Science·Adam Pallus, Mark M G Walton
Jul 8, 2020·Investigative Ophthalmology & Visual Science·Qingshu GeMinbin Yu
Sep 16, 2020·Investigative Ophthalmology & Visual Science·Santoshi Ramachandran, Vallabh E Das
Oct 17, 2019·Investigative Ophthalmology & Visual Science·Suraj Upadhyaya, Vallabh E Das
Sep 15, 2017·Journal of Neurophysiology·Mark M G Walton, Michael J Mustari
Sep 29, 2019·Investigative Ophthalmology & Visual Science·Adam PallusMark M G Walton
Nov 4, 2020·Proceedings of the National Academy of Sciences of the United States of America·Julie QuinetPaul D Gamlin
Mar 14, 2018·Experimental Eye Research·Luisa Moreira HopkerNorma Allemann
May 28, 2021·Scientific Reports·Arvind ChandnaStephen Heinen
Jul 15, 2021·Scientific Reports·Talora L MartinFatema F Ghasia
Sep 30, 2021·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·John R Economides, Jonathan C Horton

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