Strain comparisons of DFP neurotoxicity in rats

Journal of Toxicology and Environmental Health
C J Gordon, R C MacPhail

Abstract

The purpose of this study was to assess intraspecies differences in behavioral and autonomic function in three strains of rat following administration of diisopropyl fluorophosphate (DFP), an irreversible inhibitor of acetylcholinesterase activity. Male rats of the Long-Evans (LE), Fischer 344 (F344), and Sprague-Dawley (SD) strains wer administered DFP at doses of 0-1.5 mg/kg (sc). The animals were placed 60 min later into one of two motor activity chambers and tested for 30 min. Motor activity was measured using either a Doppler-based system or a commercial photocell device. Following measurement of motor activity in the Doppler system, body temperature (Tb) was measured and blood was then withdrawn by cardiac puncture and analyzed for serum cholinesterase activity (ChE). The remaining rats were retested 1 d after DFP administration in the photocell device. The results showed a significant influence of strain on the effects of DFP. Motor activity of LE rats was reduced by DFP at doses of 1.0 and 1.5 mg/kg, whereas the activity of F344 rats was reduced only at 1.5 mg/kg. The relative sensitivity of SD rats depended on the device used to measure motor activity. The SD rats resembled F344 rats in their response to DFP when motor...Continue Reading

References

Jan 1, 1990·Neurotoxicology and Teratology·F S Mohler, C J Gordon
Jan 1, 1987·Progress in Neurobiology·R W Russell, D H Overstreet
Jan 1, 1988·Journal of Toxicology and Environmental Health·C D Carrington, M B Abou-Donia
Sep 1, 1986·Regulatory Toxicology and Pharmacology : RTP·I W DavidsonR P Beliles
Jan 1, 1982·Toxicology·L G CostaS D Murphy
Jun 1, 1980·Pharmacology, Biochemistry, and Behavior·D Creel

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Citations

Nov 1, 1994·Applied Biochemistry and Biotechnology·G Lunn, E B Sansone
Mar 14, 2001·Toxicology·S Kacew
Feb 1, 1997·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S A Ferguson, R R Holson

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