Strain dependence of receptor regulation on chemical preconditioning in mice hippocampus

Neuroscience Letters
C A von ArnimMatthias W Riepe

Abstract

While one current focus for studying mechanisms of disease is investigation of transgenic mice confounding effects of the background strain often are neglected. We investigated mRNA expression of known markers of hypoxic tolerance by a semiquantitative RT-PCR (adenosine receptors (A1 and A3), nitric oxide synthases (eNOS and nNOS), APP production, progesterone receptor, and estrogen receptors alpha and beta) in CD-1, C3H, and B6 mice. We found differences in the baseline mRNA expression of adenosine A3 receptors in C3H mice and neuronal NOS in B6 mice as well as a distinct regulation of adenosine A3 receptors and estrogen receptor beta (no changes in C3H and B6 compared to upregulation in CD-1) on treatment of animals with a low dosage of 3-nitropropionate (20mg/kg body weight, i.p.). We conclude that the choice of background strain may confound interpretation of the effects of specific transgens in the study of the mechanisms of primary and induced hypoxic tolerance.

References

Sep 24, 1990·Brain Research·K KitagawaK Mikoshiba
Mar 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M W RiepeJ Hugon
Sep 26, 1997·Stroke; a Journal of Cerebral Circulation·M FujiiM A Moskowitz
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Jun 4, 1999·Stroke; a Journal of Cerebral Circulation·K KasischkeM W Riepe
Aug 5, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·N Beckmann
Apr 5, 2002·Journal of Neuroscience Research·C A F von ArnimM W Riepe

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Citations

Jan 16, 2008·CNS Drugs·Matthias W Riepe, Roman Huber
Apr 15, 2014·Neurobiology of Learning and Memory·Luciana M PereiraGrace S Pereira
Jul 2, 2016·Journal of Neurochemistry·Rodrigo A Cunha
Jul 19, 2011·Self and Identity : the Journal of the International Society for Self and Identity·William G Shadel, Daniel Cervone

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