Strain-Dependent Activity of Zika Virus and Exposure History in Serological Diagnostics

Tropical Medicine and Infectious Disease
Kelli L BarrMaureen T Long

Abstract

Zika virus (ZIKV) circulates as two separate lineages, with significant genetic variability between strains. Strain-dependent activity has been reported for dengue virus, herpes simplex virus and influenza. Strain-dependent activity of subject specimens to a virus could be an impediment to serological diagnosis and vaccine development. In order to determine whether ZIKV exhibits strain-dependent activity when exposed to antibodies, we measured the neutralizing properties of polyclonal serum and three monoclonal antibodies (ZKA185, 753(3)C10, and 4G2) against three strains of ZIKV (MR-766, PRVABC59, and R103454). Here, MR-766 was inhibited almost 60% less by ZKA185 than PRVABC59 and R103454 (p = 0.008). ZKA185 enhanced dengue 4 infection up to 50% (p = 0.0058). PRVABC59 was not inhibited by mAb 753(3)C10 while MR-766 and R103453 were inhibited up to 90% (p = 0.04 and 0.036, respectively). Patient serum, regardless of exposure history, neutralized MR-766 ~30%-40% better than PRVABC56 or R103454 (p = 0.005-0.00007). The most troubling finding was the significant neutralization of MR-766 by patients with no ZIKV exposure. We also evaluated ZIKV antibody cross reactivity with various flaviviruses and found that more patients develop...Continue Reading

References

Jan 1, 1985·The American Journal of Tropical Medicine and Hygiene·E A HenchalW E Brandt
Jul 1, 1982·The American Journal of Tropical Medicine and Hygiene·E A HenchalW E Brandt
Sep 1, 1952·Transactions of the Royal Society of Tropical Medicine and Hygiene·G W A DICKA J HADDOW
Nov 20, 2003·Reviews in Medical Virology·Ayato Takada, Yoshihiro Kawaoka
Aug 6, 2008·Emerging Infectious Diseases·Robert S LanciottiMark R Duffy
Oct 1, 2009·Emerging Infectious Diseases·Edward B Hayes
Jun 29, 2010·PLoS Neglected Tropical Diseases·Joshua M CostinScott F Michael
Oct 7, 2011·The American Journal of Tropical Medicine and Hygiene·Aaron C BraultRichard A Bowen
Dec 18, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C FilipponeN Tordo
Aug 24, 2013·Emerging Infectious Diseases·Brian R MannAlan D T Barrett
Jun 25, 2015·Microbiology Spectrum·Scott B Halstead
Feb 19, 2016·Journal of Clinical Microbiology·Jesse J Waggoner, Benjamin A Pinsky
Mar 31, 2016·The New England Journal of Medicine·Lyle R PetersenMargaret A Honein
Apr 1, 2016·Clinical Microbiology Reviews·Didier Musso, Duane J Gubler
Apr 19, 2016·Emerging Infectious Diseases·Robert S LanciottiLeticia Del Carmen Castillo Signor
Jun 25, 2016·Nature·Giovanna Barba-SpaethFélix A Rey
Aug 3, 2016·Cell Reports·Kimberly A DowdTheodore C Pierson
Aug 20, 2016·Science·Scott D Speer, Theodore C Pierson
Feb 24, 2017·Transfusion·Sally A BaylisUNKNOWN Zika Virus Collaborative Study Group
Mar 4, 2017·Emerging Infectious Diseases·Jean Michel MansuyJacques Izopet
May 16, 2017·PLoS Neglected Tropical Diseases·Bhumi PatelAravinda M de Silva
Jul 19, 2017·Proceedings of the National Academy of Sciences of the United States of America·Angel BalmasedaDavide Corti
Apr 13, 2018·Nature Communications·Gilberto A SantiagoJorge L Muñoz-Jordan
Sep 19, 2018·Emerging Infectious Diseases·Sally A Baylis, Johannes Blümel
Oct 21, 2018·Journal of Virological Methods·Anne J JääskeläinenHannimari Kallio-Kokko
Dec 14, 2018·Journal of Clinical Microbiology·Day-Yu ChaoGwong-Jen J Chang
Dec 19, 2018·The American Journal of Tropical Medicine and Hygiene·Rodion GorchakovKristy O Murray
Feb 8, 2019·PLoS Neglected Tropical Diseases·Cécile BeckSylvie Lecollinet
Apr 10, 2019·Molecular Therapy : the Journal of the American Society of Gene Therapy·Rianne N EsquivelDavid B Weiner
Apr 23, 2019·Emerging Infectious Diseases·Jolanda J C VoermansChantal B E M Reusken

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
PCR

Software Mentioned

MedCalc

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.