Strain-dependent differences in host response to Candida albicans infection in mice are related to organ susceptibility and infectious load.

Infection and Immunity
R B AshmanJ M Papadimitriou

Abstract

After systemic infection with the yeast Candida albicans, inbred mice show substantial differences in mortality, organ colonization, and severity of tissue damage. To examine the relationships between these variables, which are not directly correlated with each other, fungal colonization of the kidneys and brain was enumerated in six inbred strains that exhibit different patterns of tissue damage and mortality. Mice lacking the fifth component of complement (C5) are highly susceptible to lethal challenge, and A/J and DBA/2 mice, both C5 deficient, showed the highest colony counts in the kidneys after challenge with 10(5) blastoconidia. In contrast, colony counts in the brain of all six strains were equivalent at this challenge dose. A/J and DBA/2 mice died after challenge with 3 x 10(5) blastoconidia, but other strains showed an increase in kidney colonization, and strain-dependent differences in clearance from the brain became evident. The data suggest that mortality in A/J and DBA/2 mice is related to an unusual susceptibility of the kidneys to colonization by C. albicans and that there may be tissue-specific differences in host protective mechanisms.

References

Nov 1, 1992·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·G A MarquisS Montplaisir
Apr 1, 1987·Immunology and Cell Biology·R B Ashman, J M Papadimitriou
Nov 1, 1986·The Journal of Infectious Diseases·G MarquisP Auger
Dec 1, 1982·Infection and Immunity·R F HectorE W Carrow
Jun 1, 1993·Immunology and Cell Biology·R B AshmanJ M Papadimitriou
Apr 1, 1971·Infection and Immunity·R Morelli, L T Rosenberg

❮ Previous
Next ❯

Citations

Nov 16, 2002·Current Infectious Disease Reports·Jack D. Sobel
Mar 15, 2011·FEMS Microbiology Letters·Edina K Szabo, Donna M MacCallum
Sep 17, 2004·Genes and Immunity·A TuiteP Gros
Jun 11, 2003·Eukaryotic Cell·Jill R BlankenshipJoseph Heitman
Oct 24, 2007·Annual Review of Immunology·S M VidalP Gros
Aug 9, 2020·Frontiers in Immunology·Verena HarpfCornelia Speth
Apr 6, 2004·Immunology and Cell Biology·Robert B AshmanRobert L Clancy
May 3, 2011·PloS One·Irena RadovanovicPhilippe Gros
Oct 12, 2012·Mycopathologia·Paolo MosciAnna Vecchiarelli
Sep 3, 2016·G3 : Genes - Genomes - Genetics·Paula McCourtJoseph T Nickels
Jun 29, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Irena RadovanovicPhilippe Gros
Jan 12, 2012·International Journal of Microbiology·Donna M Maccallum
May 3, 2013·PLoS Pathogens·Mohlopheni J MarakalalaGordon D Brown
Sep 11, 2003·Medical Mycology·L CalderonD A Stevens
Sep 18, 2007·Eukaryotic Cell·Carmelle T NoriceAaron P Mitchell
Aug 1, 1997·Current Opinion in Immunology·L Romani
May 6, 2021·International Journal of Molecular Sciences·Mark Joseph Maranan DesameroShigeru Kakuta
Aug 28, 1998·Research in Immunology·R B Ashman
Aug 25, 2009·Trends in Immunology·Charlotte EsserBrigitta Stockinger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Related Papers

Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology
A FulurijaJ M Papadimitriou
Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology
A BoualiJ M Senet
© 2021 Meta ULC. All rights reserved