Strain-dependent effects of diazepam and the 5-HT2B/2C receptor antagonist SB 206553 in spontaneously hypertensive and Lewis rats tested in the elevated plus-maze

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
R N TakahashiF Chaouloff

Abstract

The 5-HT2B/2C receptor antagonist SB 206553 exerts anxiolytic effects in rat models of anxiety. However, these effects have been reported for standard rat strains, thus raising the issue of SB 206553 effects in rat strains displaying different levels of anxiety. Herein, the effects of SB 206553 in a 5-min elevated plus-maze test of anxiety were compared to those of the reference anxiolytic, diazepam, in two rat strains respectively displaying high (Lewis rats) and low (spontaneously hypertensive rats, SHR) anxiety. Diazepam (0.37, 0.75, or 1.5 mg/kg; 30 min before testing) increased in a dose-dependent manner the behavioral measures in SHR, but not in Lewis rats. On the other hand, SB 206553 (1.25, 2.5, or 5 mg/kg; 30 min before testing) failed to alter the anxiety parameters in both strains, whereas it increased closed arm entries in Lewis rats, suggesting that it elicited hyperactivity in the latter strain. Accordingly, the hypolocomotor effect of the nonselective 5-HT2B/2C receptor agonist m-chlorophenylpiperazine (1.5 mg/kg ip 20 min before a 15-min exposure to an activity cage) was prevented by the 1.25 and 2.5 mg/kg doses of SB 206553 in Lewis rats and SHR, respectively. Compared with SHR, Lewis rats may display a lower r...Continue Reading

References

May 1, 1988·British Journal of Pharmacology·G A Kennett, G Curzon
Sep 1, 1994·Pharmacology, Biochemistry, and Behavior·A P CruzF G Graeff
Apr 1, 1997·Behavioural Brain Research·A RamosF Chaouloff
May 18, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A C McCreary, K A Cunningham

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Citations

May 24, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kirsten C MorleyIain S McGregor
Apr 17, 2007·Behavioral and Brain Functions : BBF·Gustavo R BrüskeAndré Ramos
Dec 1, 2015·Pharmacology & Therapeutics·Giuseppe Di Giovanni, Philippe De Deurwaerdère
Sep 16, 2009·Life Sciences·Dimitrios KouvelasMichaela M Kraus
Feb 27, 2016·Advanced Biomedical Research·Alireza KomakiIraj Salehi
Mar 27, 2003·Behavioural Pharmacology·M DurandF Chaouloff

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