Strain-dependent recovery behavior of single chondrocytes

Biomechanics and Modeling in Mechanobiology
Adrian C ShiehKyriacos A Athanasiou

Abstract

One of the challenges facing researchers studying chondrocyte mechanobiology is determining the range of mechanical forces pertinent to the problems they study. One possible way to deal with this problem is to quantify how the biomechanical behavior of cells varies in response to changing mechanical forces. In this study, the compressibility and recovery behaviors of single chondrocytes were determined as a function of compressive strains from 6 to 63%. Bovine articular chondrocytes from the middle and deep zones were subjected to this range of strains, and digital videocapture was used to track changes in cell dimensions during and after compression. The normalized volume change, apparent Poisson's ratio, residual strain after recovery, cell volume fraction after recovery, and characteristic recovery time constant were analyzed with respect to axial strain. Normalized volume change varied as a function of strain, demonstrating that chondrocytes exhibited compressibility. The mean Poisson's ratio of chondrocytes was found to be 0.29 +/- 0.14, and did not vary with axial strain. In contrast, residual strain, recovered volume fraction, and recovery time constant all depended on axial strain. The dependence of residual strain and ...Continue Reading

References

Jan 1, 1989·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R L SahJ D Sandy
May 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·P M FreemanT P Andriacchi
Nov 1, 1995·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R L SmithD J Schurman
Jan 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R L SmithD J Schurman
Feb 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·A J ManiotisD E Ingber
Jan 13, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·P M RaganM W Lark
Jan 13, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D Shin, K Athanasiou
Feb 24, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·W R TrickeyF Guilak
Sep 20, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·P G Bush, A C Hall
Oct 25, 2001·Archives of Biochemistry and Biophysics·M JinA J Grodzinsky
Jan 10, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·B KurzA J Grodzinsky
Jan 25, 2002·Biophysical Journal·Farshid GuilakH Ping Ting-Beall
Aug 22, 2003·Journal of Biomechanical Engineering·Leonidas G AlexopoulosFarshid Guilak
Aug 22, 2003·Journal of Biomechanical Engineering·Eugene J KoayKyriacos A Athanasiou
Dec 6, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Wendy R TrickeyFarshid Guilak
Oct 12, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Eric M DarlingKyriacos A Athanasiou
Nov 3, 2004·Journal of Biomechanics·Nic D Leipzig, K A Kyriacos A Athanasiou
Oct 1, 1996·Tissue Engineering·R P Wilkes, K A Athanasiou

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Citations

Nov 4, 2006·Biomechanics and Modeling in Mechanobiology·Gerard A Ateshian
Aug 1, 2009·Biomechanics and Modeling in Mechanobiology·Gidon OfekKyriacos A Athanasiou
Jan 11, 2012·Biomechanics and Modeling in Mechanobiology·Johannah Sanchez-Adams, Kyriacos A Athanasiou
May 5, 2010·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Y LoosliJ G Snedeker
Aug 22, 2003·Journal of Biomechanical Engineering·Leonidas G AlexopoulosFarshid Guilak
Jun 12, 2014·Tissue Engineering. Part a·Regina F MacBarbKyriacos A Athanasiou
Oct 21, 2009·Progress in Biophysics and Molecular Biology·Yongdong FengChung-Che Chang
Mar 6, 2009·Journal of Biomechanics·Gidon OfekKyriacos A Athanasiou
Jan 16, 2015·Computer Methods in Biomechanics and Biomedical Engineering·Trung Dung NguyenYuantong Gu
Oct 3, 2012·Journal of the Mechanical Behavior of Biomedical Materials·William RonanJ Patrick McGarry
Oct 19, 2006·Osteoarthritis and Cartilage·A C Shieh, K A Athanasiou
Dec 11, 2007·Biophysical Journal·Nic D Leipzig, Kyriacos A Athanasiou
Dec 13, 2016·Soft Matter·Kristina HaaseAndrew E Pelling
Jan 20, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Xuejie YiBo Chang

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