Dec 19, 2014

Strain-dependent variations in stress coping behavior are mediated by a 5-HT/GABA interaction within the prefrontal corticolimbic system

The International Journal of Neuropsychopharmacology
Diego AndolinaS Puglisi-Allegra

Abstract

Serotonin and γ-aminobutyric acid (GABA) transmission is crucial in coping strategies. Here, using mice from 2 inbred strains widely exploited in behavioral neurochemistry, we investigated whether serotonin transmission in medial prefrontal cortex and GABA in basolateral amygdala determine strain-dependent liability to stress response and differences in coping. C57BL/6J mice displayed greater immobility in the forced swimming test, higher serotonin outflow in medial prefrontal cortex, higher GABA outflow in basolateral amygdala induced by stress, and higher serotonin 1A receptor levels in medial prefrontal cortex accompanied by lower GABAb receptor levels in basolateral amygdala than DBA/2J mice. In assessing whether serotonin in medial prefrontal cortex determines GABA functioning in response to stress and passive coping behavior in C57BL/6J and DBA/2J mice, we observed that selective prefrontal serotonin depletion in C57BL/6J and DBA/2J reduced stress-induced GABA outflow in basolateral amygdala and immobility in the forced swimming test. These results show that strain-dependent prefrontal corticolimbic serotonin/GABA regulation determines the strain differences in stress-coping behavior in the forced swimming test and point ...Continue Reading

Mentioned in this Paper

Limbic System
Biological Adaptation to Stress
Serotonin Effect
Adrenal Cortex Diseases
Prefrontal Cortex
Serotonin Measurement
Serotonin
Inbred Strain
Receptors, Tryptamine
Receptor, Serotonin,5-HT1A

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