Strain-dependent vascular remodeling: the "Glagov phenomenon" is genetically determined

Circulation
Vyacheslav A Korshunov, Bradford C Berk

Abstract

Atherosclerosis of the carotid artery, called intima-media thickening (IMT), is a form of vascular remodeling that is an important predictor for cardiovascular events and has a strong genetic component. Recently, we established a mouse model of vascular remodeling based on partial ligation of the carotid, which is relevant to the "Glagov phenomenon." We hypothesized that there would be genetically determined differences in outward remodeling and IMT induced by carotid flow alterations. We compared vascular remodeling among 5 inbred strains of mice. Despite similar changes in flow among the strains in the left carotid artery (LCA), we observed dramatic differences in remodeling of the partially ligated LCA relative to control. The smallest IMT volume (26+/-3 microm3) was found in C3H/HeJ mice, and the largest were in SJL/J (59+/-10 microm3) and FVB/NJ (81+/-6 microm3). Shear stress did not differ after ligation among strains. Lumen area decreased only when stenosis was > or =55%. IMT correlated significantly with outward remodeling among inbred strains (except C3H). There were significant strain-dependent differences in remodeling index (measured as vessel area/IMT), which suggest fundamental alterations in sensing or transducin...Continue Reading

References

May 28, 1987·The New England Journal of Medicine·S GlagovG J Kolettis
Mar 1, 1986·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·B L LangilleR L Kline
May 4, 2000·The American Journal of Pathology·K J HarmonV Lindner
May 11, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Vladimir ShustermanBarry London
Aug 13, 2002·Journal of Hypertension·Stéphane Laurent
Mar 19, 2003·Current Opinion in Lipidology·Faiez Zannad, Athanase Benetos
Apr 5, 2003·Circulation Research·Jamila IbrahimBradford C Berk
Oct 25, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Vyacheslav A Korshunov, Bradford C Berk

❮ Previous
Next ❯

Citations

Sep 3, 2010·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Jan-Christian ReilMichael Böhm
Mar 18, 2005·Biomechanics and Modeling in Mechanobiology·Francesco Migliavacca, Gabriele Dubini
Apr 17, 2008·Annals of Biomedical Engineering·Roger Tran-Son-TayScott A Berceli
Nov 9, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Masahiro TerashimaMichael V McConnell
Feb 25, 2006·The Canadian Journal of Cardiology·Bradford C Berk, Vyacheslav A Korshunov
Dec 10, 2008·The Journal of Experimental Medicine·Paul C Y TangGeorge Tellides
Feb 4, 2009·Antioxidants & Redox Signaling·Hanke L MatlungEd VanBavel
Aug 18, 2010·Antioxidants & Redox Signaling·Amir RezvanHanjoong Jo
Jul 10, 2009·Cardiovascular Research·Eric Thorin, Nathalie Thorin-Trescases
Dec 26, 2009·American Journal of Physiology. Heart and Circulatory Physiology·A N SimpkinsJ D Imig
Sep 4, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Crisanto S EscanoPedro A Jose
Jan 24, 2006·Journal of Vascular Research·Michèle CoutardJean-Baptiste Michel
Oct 25, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Vyacheslav A Korshunov, Bradford C Berk
May 2, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Hou-Yu ChiangJane Sottile
Apr 25, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Zhongming Chen, Ellie Tzima
Nov 13, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Xi ChuFrancis J Miller
Nov 6, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Baohua YangVictor Rizzo
Dec 20, 2008·Stroke; a Journal of Cerebral Circulation·Jamila Ibrahim, Bradford C Berk
Feb 7, 2016·Computers in Biology and Medicine·Richard I HanGerd Brunner
Mar 9, 2010·Experimental Lung Research·Karen C YoungCleide Suguihara
Jul 5, 2008·Experimental Lung Research·Yuji TadaJames West
Aug 19, 2007·Chronobiology International·Naoki OhkuraShuichi Horie
Dec 4, 2010·Journal of the American College of Cardiology·Florian CustodisUlrich Laufs
Apr 29, 2009·Thrombosis Research·Thomas A WhiteRobert D Simari
Dec 27, 2005·The American Journal of Cardiology·Charles L FeldmanPeter H Stone
Mar 21, 2006·Medical Hypotheses·Yiannis S Chatzizisis, George D Giannoglou
Jun 25, 2010·Journal of Vascular Surgery·Peng YuC Keith Ozaki
Jun 7, 2011·The American Journal of Pathology·Peng YuC Keith Ozaki
Apr 28, 2012·The American Journal of Pathology·Janice Gerloff, Vyacheslav A Korshunov
Jul 30, 2016·Pediatric Neurology·Jorina ElbersSusanne Benseler

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.