PMID: 3753197Jul 1, 1986Paper

Strain difference in mercury excretion in methylmercury-treated mice

Archives of Toxicology
A Yasutake, K Hirayama

Abstract

The strain differences in mercury excretion and organ distribution after administration of methylmercuric chloride (5 mg/kg) were studied in male mice of four strains, C57BL/6N, BALB/cA, C3H/HeN and AKR. The urinary excretion rate of mercury for 5 days following administration was 3.9-4.7 times higher in the C57BL strain than in the other three strains, whereas the mercury level in feces was highest in the AKR strain. Although the blood mercury concentration in the C57BL strain was almost half that in the others up to the 5th day, the plasma levels did not vary so widely. C57BL showed the highest ratio of plasma to whole blood mercury level, which was thought to originate from the lower affinity of methylmercury for hemoglobin. The variation of the plasma/whole blood ratios was rather small throughout the experimental period in each strain examined. In the C57BL strain, the mercury levels in brain, liver, kidney and blood were significantly lower on and after the 5th day than in the other three strains, probably because of the rapid elimination of body mercury into urine, but the mercury uptake by the brain and kidney 5 min after administration was at a rather higher rate than in the other strains. On the other hand, the highes...Continue Reading

References

Apr 1, 1973·Toxicology and Applied Pharmacology·F IversonH L Trenholm
Jun 1, 1974·Archives of Environmental Health·H al-Shahristani, K M Shihab
Nov 1, 1984·Archives of Environmental Health·I R RowlandR A Doherty
Jul 1, 1983·Toxicology and Applied Pharmacology·R DoiK Nakaya
Dec 1, 1960·American Industrial Hygiene Association Journal·M B JACOBSH GILBERT

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Citations

Jan 1, 1989·Archives of Toxicology·A YasutakeM Inoue
Jan 1, 1990·Archives of Toxicology·A YasutakeM Inoue
Jul 1, 1989·Biological Trace Element Research·K PeterssonM Vahter
Dec 7, 2010·Archives of Toxicology·Masaaki NakamuraMasumi Marumoto
Jan 1, 1986·Journal of Toxicology and Environmental Health·M InouyeK Hirayama
Sep 1, 1992·Journal of Toxicology and Environmental Health·J B Nielsen
May 1, 1997·Toxicology and Applied Pharmacology·P GriemE Gleichmann

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