Strain differences affect the induction of status epilepticus and seizure-induced morphological changes

The European Journal of Neuroscience
B XuR J Racine

Abstract

Genetic deficits have been discovered in human epilepsy, which lead to alteration of the balance between excitation and inhibition, and ultimately result in seizures. Rodents show similar genetic determinants of seizure induction. To test whether seizure-prone phenotypes exhibit increased seizure-related morphological changes, we compared two standard rat strains (Long-Evans hooded and Wistar) and two specially bred strains following status epilepticus. The special strains, namely the kindling-prone (FAST) and kindling-resistant (SLOW) strains, were selectively bred based on their amygdala kindling rate. Although the Wistar and Long-Evans hooded strains experienced similar amounts of seizure activity, Wistar rats showed greater mossy fiber sprouting and hilar neuronal loss than Long-Evans hooded rats. The mossy fiber system was affected differently in FAST and SLOW rats. FAST animals showed more mossy fiber granules in the naïve state, but were more resistant to seizure-induced mossy fiber sprouting than SLOW rats. These properties of the FAST strain are consistent with those observed in juvenile animals, further supporting the hypothesis that the FAST strain shares circuit properties similar to those seen in immature animals. ...Continue Reading

References

May 20, 1991·Brain Research. Developmental Brain Research·E F SperberS L Moshé
Mar 1, 1991·Neuroreport·G T GoldenR G Fariello
Jul 1, 1989·Brain Research. Brain Research Reviews·R S Fisher
Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
May 1, 1967·The Journal of Heredity·J L Fuller, F H Sjursen
Jun 1, 1981·Experimental Neurology·J P Pinel
Jan 1, 1981·Developmental Psychobiology·S L Moshé
Feb 1, 1995·Epilepsy Research·G T GoldenP F Reyes
Jul 1, 1994·Brain & Development·C G Wasterlain, Y Shirasaka
Feb 1, 1994·Synapse·M FrotscherU Misgeld
Jan 24, 1998·Brain Research·B AdamsR J Racine
Jan 8, 1999·Experimental Neurology·W LöscherU Ebert
Dec 28, 1999·Brain Research. Developmental Brain Research·L HuangG L Holmes
Jan 21, 2000·Hippocampus·V Ramírez-AmayaF Bermúdez-Rattoni
Nov 14, 2000·Trends in Neurosciences·Y Ben-Ari, R Cossart
Mar 29, 2001·Physiology & Behavior·I A KliouevaS A Chepurnov
Jun 21, 2001·Genomics·W N FrankelH S White
Apr 18, 2002·Brain Pathology·Douglas A CoulterWolfgang Löscher
Jul 30, 2002·Progress in Brain Research·Robert KotloskiThomas Sutula
Jul 30, 2002·Progress in Brain Research·Charles E Ribak, Khashayar Dashtipour
Aug 2, 2002·Epilepsy Research·Dan C McIntyreKrista Gilby
Aug 2, 2002·Epilepsy Research·J P LeiteE A Cavalheiro
Nov 13, 2002·Neurology·Gregory L Holmes
Nov 13, 2002·Neurology·John S Duncan

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Citations

Dec 30, 2011·Sleep & Breathing = Schlaf & Atmung·Angela L McDowellPingfu Feng
Apr 16, 2010·Journal of Neurotrauma·Wendy Murdock ReidDong Sun
May 1, 2008·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Angelo CarneiroJosé Paulo Andrade
Aug 18, 2009·Epilepsia·Aristea S Galanopoulou, Solomon L Moshé
Jan 30, 2008·Epilepsy Research·Vassiliki Aroniadou-AnderjaskaMaria F M Braga
Apr 24, 2012·Journal of Neurochemistry·Katherine E HornTimothy E Kennedy
Feb 19, 2013·Epilepsy & Behavior : E&B·Krista L Gilby, Terence J O'Brien
Mar 10, 2009·The International Journal of Neuropsychopharmacology·Jennifer FrançoisAstrid Nehlig
Aug 31, 2016·Annual Review of Pharmacology and Toxicology·P H HutsonA J Cross
Oct 13, 2019·The European Journal of Neuroscience·Laëtitia Chauvière
Sep 28, 2018·Epilepsy Research·Victor R SantosPatrick A Forcelli
Aug 30, 2021·Laboratory animal research·Cheryl TyszkiewiczChris Somps

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