Strain differences in delay discounting between Lewis and Fischer 344 rats at baseline and following acute and chronic administration of d-amphetamine.

Pharmacology, Biochemistry, and Behavior
Sally L HuskinsonKaren G Anderson

Abstract

Stimulant drugs have been shown either to increase or decrease rates of delay discounting (impulsive choice). These mixed findings may result from genetic, neurochemical, or environmental factors. Lewis (LEW) and Fischer 344 (F344) rats have neurochemical and behavioral differences that may be relevant to delay discounting and were used to examine effects of acute and chronic administration of d-amphetamine (d-AMP) on impulsive choice using a within-session delay-discounting procedure. Male LEW (n=8) and F344 (n=8) rats chose between one food pellet delivered immediately and three food pellets delivered after an increasing delay. Saline and d-AMP (0.1, 0.3, 1.0, and 1.7 mg/kg) were tested acutely and during chronic d-AMP exposure. Choice for the larger reinforcer decreased as the delay to its presentation increased for both strains at baseline. LEW rats made more impulsive choices than F344 rats as indicated by shorter indifference points, and this is consistent with previous research. Acute administration of d-AMP dose dependently increased larger-reinforcer choice and area under the curve (AUC) for LEW, but not F344 rats. During chronic exposure to d-AMP, larger-reinforcer choice and AUC increased relative to acute administra...Continue Reading

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Citations

Apr 1, 2014·Annual Review of Clinical Psychology·Warren K BickelJames G Murphy
Sep 17, 2013·Psychopharmacology·K Z KolokotroniA A Harrison
Feb 14, 2015·Current Addiction Reports·Jessica WeaferHarriet de Wit
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Apr 15, 2015·Journal of the Experimental Analysis of Behavior·Derek A PopeBlake A Hutsell
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Jul 31, 2013·Behavioural Processes·Sally L Huskinson, Karen G Anderson
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Nov 5, 2020·Pharmacology, Biochemistry, and Behavior·Derek A PopeM Christopher Newland

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