PMID: 3771618Jan 1, 1986Paper

Strain differences in mice with invasive bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl)nitrosamine

Journal of Cancer Research and Clinical Oncology
M OhtaniS Fukushima

Abstract

Papillary superficial and nonpapillary invasive bladder carcinomas of humans are two disease entities exhibiting completely different biological behavior. Studies were performed on the susceptibilities of various strains of mice to induction of bladder carcinomas by N-butyl-N-(4-hydroxybutyl)nitrosamine (BHBN), and the type of carcinomas that developed. BHBN at concentrations of 0.05% and 0.01% in drinking water was given to female mice of strains A/Jax, AKR/Jax, C3H/He, DBA/2, and C57BL/6 for 22 weeks. The incidence of nonpapillary invasive bladder carcinomas in these strains was 40%, 100%, 100%, 89%, and 89%, respectively, in groups treated with 0.05% BHBN and 30%, 60%, 60%, 90%, and 40%, respectively, in groups treated with 0.01% BHBN. At both levels BHBN and in all strains the bladder carcinomas induced were of the nonpapillary invasive type.

References

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Citations

Jan 1, 1992·International Urology and Nephrology·H TsujihashiT Kurita
Sep 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R Oyasu
Jul 11, 2006·Cancer Science·Tadao Kakizoe
Jun 22, 2016·Investigative and Clinical Urology·Makito MiyakeYoshihiko Hirao
Dec 28, 2012·Molecular Cancer Therapeutics·David J DeGraffUNKNOWN Translational Science Working Group of the Bladder Advocacy Network Think Tank

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