Strain differences in sensitivity of rats to Mycoplasma arthritidis ISR 1 infection are under multiple gene control.

Infection and Immunity
A BinderK Wonigeit

Abstract

At least 5 female rats from each of 24 inbred (ACI, AS, BDIX, BH, BN, BS, BUF, DA, LE, LEW, MWF, OM, SPRD-Cu3, W-Krypt, and WKY), RT1 congenic [BH.1L(LEW), LEW.1A(AVN), LEW.1C(WIST), LEW.1LV3(BH), LEW.1K(SHR), and LEW.1N(BN)], and F1 hybrid [(LEW x BN)F1, (LEW.1W x LEW.1A)F1, and (LEW x LEW.1W)F1] strains, representing eight independent major histocompatibility complex (MHC) haplotypes (a, b, c, dv1, k, l, n, and u) and five related RT1 haplotypes (av1, lv1, lv3, uv2, and uv3), were inoculated intravenously with Mycoplasma arthritidis, and the severity of the polyarthritis that developed was determined by estimating arthritis scores and weight reductions. The 24 inbred, congenic, and F1 hybrid rat strains differed considerably in their sensitivity to infection with M. arthritidis and in the severity of the polyarthritis that they developed. Statistical evaluation showed that in the acute phase (days 1 to 42 after infection) as well as in the chronic phase (days 39 to 121 after infection) of the disease, the means of the arthritis scores for the strains form a continuous variation without significant interruptions, with the very sensitive LEW rats, the RT1 congenic rats on LEW background, the F1 hybrids with LEW, and the MWF, BS...Continue Reading

References

Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·E M SternbergR L Wilder

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Citations

May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·J C LorentzenH Luthman
Jan 1, 1990·Scandinavian Journal of Rheumatology. Supplement·P Ivanyi
Jan 1, 1993·Mammalian Genome : Official Journal of the International Mammalian Genome Society·E F RemmersR L Wilder
Mar 1, 1995·Clinical and Experimental Immunology·H SustackovaT F Cruz
Nov 1, 1992·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·F IglauerG O Schwarz
Jan 1, 1993·Mammalian Genome : Official Journal of the International Mammalian Genome Society·E F RemmersR L Wilder
Feb 14, 2004·Transfusion·Boris ZavizionBernadette Alford
May 18, 2019·Laboratory Animals·Axel Kornerup HansenCamilla Hartmann Friis Hansen
Jun 3, 2021·Animals : an Open Access Journal From MDPI·Stephanie Buchheister, André Bleich
Jun 2, 1998·Rheumatic Diseases Clinics of North America·J B ZabriskieA Gibofsky

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