PMID: 9024935Jun 1, 1996Paper

Strain differences in the cytotoxic activity and TNF production of murine macrophages stimulated by lentinan

International Journal of Immunopharmacology
C KerékgyártóJ Fachet

Abstract

The effect of lentinan, a glucan type immunomodulatory polysaccharide was studied on the antitumor cytotoxicity and on the TNF secretion of peritoneal macrophages in inbred H-2 congeneic mouse strains under in vivo and in vitro conditions. The cytotoxic activity and TNF secretion of murine macrophages was found to be elevated by lentinan in vitro and in vivo conditions. The effectiveness of lentinan to induce cytotoxicity and TNF secretion was highly influenced by the genotype of the host. The increased cytotoxicity of macrophages was modified by the H-2 and the background genes. The black background and the H-2a and H-2d haplotypes were associated with high responsiveness, while the albino and agouti background and the H-2b and the H-2k haplotypes with low responsiveness to lentinan treatment. The degree of TNF secretion of macrophages stimulated by lentinan was influenced by the H-2 genes only. Similarly, to the macrophage cytotoxicity the TNF secretion in the H-2a and H-2d haplotypes were found to be high, on the other hand, in the H-2b and H-2k were low.

References

Jan 1, 1991·International Journal of Immunopharmacology·Y Y MaedaH Yonekawa
Aug 7, 1990·Journal of Immunological Methods·M FerrariA M Isetta
Feb 1, 1989·The Tohoku Journal of Experimental Medicine·Y YajimaT Toyota
Jan 1, 1988·Immunopharmacology and Immunotoxicology·G PéterY Kaneko
Jun 1, 1987·Chemical & Pharmaceutical Bulletin·H NanbaH Kuroda
Jun 1, 1987·Chemical & Pharmaceutical Bulletin·H Nanba, H Kuroda
Nov 6, 1986·Journal of Immunological Methods·S M Kramer, M E Carver
Oct 1, 1982·Immunopharmacology·J P FruehaufR B Herberman
Mar 15, 1980·International Journal of Cancer. Journal International Du Cancer·J ZákányJ Fachet
Jan 1, 1993·Cancer Immunology, Immunotherapy : CII·A LadányiK Lapis

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Citations

Sep 3, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M L PenichetS L Morrison
May 25, 2013·Journal of Clinical Biochemistry and Nutrition·Masashi Mizuno, Yosuke Nishitani
Oct 8, 2009·Bioscience, Biotechnology, and Biochemistry·Masashi MizunoKazuki Kanazawa
Nov 19, 2013·Critical Reviews in Food Science and Nutrition·Xiaofei XuXuewu Zhang
Sep 7, 2016·International Immunopharmacology·Ken-Ichiro MinatoIrma van Die
Sep 17, 2002·The American Journal of Chinese Medicine·Tsutomu NakadaToshihiko Hanawa
Nov 1, 2011·Immune Network·Hyung Sook KimSang-Bae Han
Nov 24, 1999·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·M R KeatsS F Whitsett
Jun 15, 2017·Mediators of Inflammation·Ken-Ichiro MinatoMasashi Mizuno

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