Strain echocardiography combined with pharmacological stress test for early detection of anthracycline induced cardiomyopathy

Journal of Pharmacological and Toxicological Methods
Jeffrey BurdickRobert Coatney

Abstract

Advances in echocardiography, including 2-D speckle tracking to quantitate myocardial strain and strain rate, have improved myocardial functional and mechanical evaluation and may provide a more sensitive assessment of cardiac functional and mechanical changes. Additionally, evaluating myocardial performance induced by a pharmacologic stress test (dobutamine infusion) may further improve the evaluation of potential changes in cardiac function. This study evaluates the use of 2-D speckle tracking strain echocardiography (2DSE) combined with a dobutamine stress test to detect doxorubicin induced cardiomyopathy in the rat. Rats were dosed once per week with 2 mg/kg doxorubicin for 6 weeks. Echocardiography was performed weekly at rest and during dobutamine infusion (20 mcg/kg/min IV). Throughout the study there were no differences between control and doxorubicin treated groups at rest for radial strain, circumferential strain, fractional shortening (FS), or heart rate (HR). During dobutamine infusion, radial strain, circumferential strain, FS, and HR similarly increased significantly in both the control and doxorubicin treated groups at weeks 0, 1, and 2. At week 3 there was a significant attenuation of the increase in radial stra...Continue Reading

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Citations

Feb 6, 2017·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·João Lucas O'ConnellMarcus V Simões
Jul 7, 2017·Expert Opinion on Drug Metabolism & Toxicology·Neha BansalSteven E Lipshultz
Nov 24, 2020·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Giuseppina NovoMaurizio Galderisi

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