Strain-Guided Management of Potentially Cardiotoxic Cancer Therapy.

Journal of the American College of Cardiology
Paaladinesh ThavendiranathanSUCCOUR investigators

Abstract

In patients at risk of cancer therapy-related cardiac dysfunction (CTRCD), initiation of cardioprotective therapy (CPT) is constrained by the low sensitivity of ejection fraction (EF) for minor changes in left ventricular (LV) function. Global longitudinal strain (GLS) is a robust and sensitive marker of LV dysfunction, but existing observational data have been insufficient to support a routine GLS-guided strategy for CPT. This study sought to identify whether GLS-guided CPT prevents reduction in LVEF and development of CTRCD in high-risk patients undergoing potentially cardiotoxic chemotherapy, compared with usual care. In this international, multicenter, prospective, randomized controlled trial, 331 anthracycline-treated patients with another heart failure risk factor were randomly allocated to CPT initiation guided by either ≥12% relative reduction in GLS (n = 166) or >10% absolute reduction of LVEF (n = 165). Patients were followed for EF and development of CTRCD (symptomatic EF reduction of >5% or >10% asymptomatic to <55%) over 1 year. Of 331 randomized patients, 2 died, and 22 withdrew consent or were lost to follow-up. Among 307 patients (age: 54 ± 12 years; 94% women; baseline LVEF: 59 ± 6%; GLS: -20.6 ± 2.4%) with a m...Continue Reading

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Citations

Jan 7, 2021·European Heart Journal Cardiovascular Imaging·Christopher E D SaundersonCharlotte H Manisty
Jan 23, 2021·Breast Cancer Research and Treatment·Lua Jafari, Nausheen Akhter
Feb 12, 2021·European Heart Journal Cardiovascular Imaging·Jutta Bergler-Klein
Jan 30, 2021·Journal of the American College of Cardiology·Javid J Moslehi, Ronald M Witteles
Mar 22, 2021·JACC. Cardiovascular Imaging·Jennifer H Jordan, W Gregory Hundley
Apr 10, 2021·Clinical Oncology : a Journal of the Royal College of Radiologists·M S AndresA R Lyon
May 1, 2021·Journal of Clinical Medicine·Michał BohdanEwa Lewicka
May 8, 2021·JACC. Cardiovascular Imaging·Raymond Y Kwong, Y S Chandrashekhar
May 14, 2021·The International Journal of Cardiovascular Imaging·Srilakshmi VallabhaneniDaniel J Lenihan
Jun 5, 2021·Journal of the American College of Cardiology·Wenbing JiangHe Huang
Jun 5, 2021·Journal of the American College of Cardiology·Thomas H MarwickUNKNOWN SUCCOUR investigators
Aug 16, 2021·JACC. Heart Failure·Edgar Argulian, Jagat Narula
Aug 17, 2021·JACC. CardioOncology·Rebecca DobsonUNKNOWN British Society of Echocardiography (BSE) and theBritish Society of Cardio-Oncology (BCOS)
Aug 28, 2021·European Heart Journal·Theresa A McDonaghUNKNOWN ESC Scientific Document Group
Aug 31, 2021·Circulation·Torbjørn Omland
Sep 21, 2021·Frontiers in Cardiovascular Medicine·Christopher YuKazuaki Negishi
Nov 11, 2021·Circulation·Vlad G ZahaUNKNOWN American Heart Association Cardio-Oncology Subcommittee of the Council on Clinical Cardiology; and Council on Genomic and Pr
Nov 17, 2021·The International Journal of Cardiovascular Imaging·Géris MazzuttiAngela Barreto Santiago Santos

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