Strain-promoted double-click reaction for chemical modification of azido-biomolecules

Organic & Biomolecular Chemistry
Isao KiiTakamitsu Hosoya

Abstract

The strain-promoted "double-click" (SPDC) reaction using Sondheimer diyne, a novel convergent method conjugating three molecules spontaneously, has enabled us to readily modify an azido-biomolecule with a small reporter azido-molecule.

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