PMID: 3764320Jan 1, 1986Paper

Strain-related susceptibility to nephrotoxicity induced by aspirin and phenylbutazone in rats

Toxicologic Pathology
R A Owen, R Heywood

Abstract

Single doses of aspirin induce scattered foci of necrosis of proximal tubules in some strains of rats, whereas acute or sub-acute administration of phenylbutazone causes renal papillary necrosis. Initially, using Sprague-Dawley rats of CFY and CD strains, it became clear that these rats were not as susceptible to these drugs as the literature suggested. Aspirin-induced necrosis was apparently sex-related, being seen in females but could be induced by hormone treatment in males. Male Wistar and Sprague-Dawley rats had reacted differently to administration of phenylbutazone for two weeks. Two experiments were performed with four rat strains: Wistar, Lister-Hooded, Sprague-Dawley, and Fischer-344. The rats were six weeks old at the start of the experiments. Five males and five females of each strain were gavaged with either a single dose of 1,000 mg/kg of aspirin or 200 mg/kg phenylbutazone once daily for four weeks. The drugs were suspended in methylcellulose, which was given to equal numbers of control male and female rats in each experiment. The rats were maintained under standard conditions. Blood and 18-hour overnight urine samples were collected prior to sacrifice. There were no strain-related differences in the types of ren...Continue Reading

References

May 1, 1971·Toxicology and Applied Pharmacology·D L BokelmanP F Stonier
Jun 1, 1983·Toxicology Letters·R A Owen, R Heywood
Aug 1, 1983·Toxicology Letters·R A Owen, R Heywood
Mar 1, 1980·Toxicology Letters·R A Owen, R Heywood

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Citations

Apr 1, 1988·Archives of Toxicology·K FentG Zbinden
Feb 1, 1997·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·E HolmesJ K Nicholson
Aug 7, 2012·Journal of Veterinary Internal Medicine·G NobleS L Raidal
Jul 10, 2012·Expert Opinion on Drug Metabolism & Toxicology·Andrea TrevisanPatrizia Cristofori
Apr 6, 2013·Journal of Applied Toxicology : JAT·Yoko NishimuraTakeki Uehara
Dec 6, 2006·The Journal of Veterinary Medical Science·Nanae MurataShusaku Suzuki
Mar 21, 1998·Toxicologic Pathology·J W Verlander
Mar 21, 1998·Toxicologic Pathology·P H Bach, T K Nguyen
Jan 1, 1988·Annals of the New York Academy of Sciences·E SolciaJ M Polak
Jan 7, 2003·Toxicologic Pathology·Amy E Brix

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