Strain-specific differential expression of astrocytes and microglia in the mouse hippocampus

Brain and Behavior
Jong Whi KimYeo Sung Yoon

Abstract

Genetic background influences neurotransmitter expression and function of the hippocampus. Genetic background influences the phenotype of the hippocampus, but expression of neuroglia in hippocampus has not been well established dependent on various mouse strains. In this study, we investigated the effects of genetic background on cell population of astrocytes and microglia in eight widely used inbred strains (C57BL/6J, A/J, BALB/c, C3H/HeJ, FVB, 129/SvJ, DBA/1, and DBA/2) and one outbred strain (ICR). In all mouse strains, glial fibrillary acidic protein (GFAP)-immunoreactive astrocytes and ionized calcium-binding adaptor molecule 1 (Iba-1)-immunoreactive microglia were found in almost all layers of hippocampal CA1-4 regions and the dentate gyrus. We observed significant differences in the number of astrocytes and microglia. In the CA1 and CA3 regions, the number of GFAP-immunoreactive astrocytes was highest in the C3H/HeJ strain, and lowest in the 129/SvJ and FVB strains. In the polymorphic layer of the dentate gyrus, the number was highest in the DBA/1 strain and lowest in the 129/SvJ strain. Among the nine mouse strains, the number of Iba-1-immunoreactive microglia was highest in the CA1 and CA3 regions in the ICR and in the...Continue Reading

References

Jan 1, 1992·Neuroscience·L J LawsonS Gordon
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·G KempermannF H Gage
Jan 8, 1999·Neurobiology of Aging·J M LongP R Mouton
Jun 6, 2000·Learning & Memory·P V NguyenR Bourtchouladze
Apr 27, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F C GomesV Moura Neto
Feb 21, 2002·Vision Research·B ChangJ R Heckenlively
Mar 23, 2002·Science·Eric C BeattieRobert C Malenka
Dec 24, 2002·Nature Neuroscience·Keith K MuraiElena B Pasquale
May 8, 2004·Bioinformatics·Stephen C GrubbMolly A Bogue
Oct 20, 2005·Neuroscience Letters·Troy L CarterSam Gandy
Dec 24, 2005·Nature Reviews. Neuroscience·N Joan AbbottElisabeth Hansson
Jun 21, 2006·Human Molecular Genetics·Giovanna SebastianiPatrick Tremblay
Sep 1, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael HaberKeith K Murai
Aug 30, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lizhen LiMilos Pekny
Feb 6, 2009·Nature·Nicola J Allen, Ben A Barres
Mar 9, 2010·CNS & Neurological Disorders Drug Targets·Carol A Colton, Donna M Wilcock
Jan 10, 2012·Trends in Neurosciences·Hideji Murakoshi, Ryohei Yasuda
May 11, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jana VukovicPerry F Bartlett
Jul 4, 2012·Neurobiology of Disease·Karlie A Intlekofer, Carl W Cotman
Sep 18, 2012·Nature Neuroscience·Randolph S AshtonDavid V Schaffer
Apr 30, 2013·Current Drug Targets·Alberto Pérez-Alvarez, Alfonso Araque
Dec 27, 2013·Neural Plasticity·Yusuke OtaRobert M Hallock
Feb 21, 2014·Nature Reviews. Neuroscience·David M BannermanPeter H Seeburg
Feb 11, 2015·Cold Spring Harbor Perspectives in Biology·Won-Suk ChungCagla Eroglu

❮ Previous
Next ❯

Software Mentioned

SPSS
StereoInvestigator

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.