PMID: 2506597Jan 1, 1989Paper

Strain-specific effects of antidepressants on escape deficits induced by inescapable shock

Psychopharmacology
N Shanks, H Anisman

Abstract

The effects of several antidepressants (desmethylimipramine, amitriptyline and bupropion) on escape deficits induced by inescapable shock were assessed in four strains of mice. The extent of the escape interference engendered by inescapable shock varied across strains of mice. These deficits of escape performance were differentially affected by the drug treatments across strains. Repeated administration of desmethylimipramine eliminated the escape interference in A/J, but did not affect the performance in Balb/cByJ, C57BL/6J or CD-1 mice. Bupropion, in contrast, had a modest effect only in CD-1 mice. Unlike these compounds, the 5-HT reuptake blocker, amitriptyline, was found to influence escape performance irrespective of whether the drug was acutely or chronically applied. It is suggested that (a) the relative contributions of various mechanisms subserving the escape interference may vary across strains of mice, hence accounting for the strain-specific effects of the drug treatments, and (b) various antidepressants influence performance by affecting different components of the behavioral output, some of which may be apparent after acute treatment while others are expressed only after repeated treatment with the compound.

References

Jan 1, 1987·Progress in Neuro-psychopharmacology & Biological Psychiatry·M Schmutz
Nov 1, 1984·Pharmacology, Biochemistry, and Behavior·R C DruganS F Maier
Jan 1, 1984·Progress in Neuro-psychopharmacology & Biological Psychiatry·R M ZacharkoH Anisman
Jun 9, 1980·Brain Research·H AnismanL S Sklar

❮ Previous
Next ❯

Citations

Aug 21, 1990·European Journal of Pharmacology·R Trullas, P Skolnick
Jul 1, 1990·Pharmacology, Biochemistry, and Behavior·N ShanksH Anisman
Jun 1, 1992·Pharmacology, Biochemistry, and Behavior·J GriffithsH Anisman
Aug 1, 1994·Pharmacology, Biochemistry, and Behavior·S N Pal, P C Dandiya
Sep 1, 1994·Pharmacology, Biochemistry, and Behavior·N ShanksH Anisman
Jan 1, 1990·Pharmacology & Therapeutics·H Anisman, R M Zacharko
Jun 1, 1996·Brain Research. Cognitive Brain Research·J S Andrews
Sep 6, 2000·Pharmacology, Biochemistry, and Behavior·B J CaldaroneM R Picciotto
Sep 3, 2005·Nature Reviews. Drug Discovery·John F Cryan, Andrew Holmes
Nov 22, 2005·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Anthony S RauhutMichael T Bardo
Sep 28, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Masato FukuiWilliam C Wetsel
Apr 22, 2008·Neuroscience and Biobehavioral Reviews·Hymie AnismanJohn D H Stead
Sep 2, 2006·Biological Psychiatry·Catharine H DumanRonald S Duman
Apr 25, 2006·Biological Psychiatry·Ronald S Duman, Lisa M Monteggia
Jan 1, 1991·Neuroscience and Biobehavioral Reviews·R M Zacharko, H Anisman
Dec 3, 2014·European Journal of Pharmacology·Barbara J CaldaroneSarah L King
Aug 28, 2012·Journal of Molecular and Cellular Cardiology·Lei LiToshiyuki Sasaguri
Jun 8, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·P SkolnickF P Bymaster
Apr 19, 2008·European Journal of Pharmacology·Christiaan H VinkersLucianne Groenink
Apr 23, 2008·Current Protocols in Neuroscience·H Anisman, Z Merali

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.