PMID: 6406657Apr 1, 1983Paper

Strain specific protective immunity against Trypanosoma cruzi

The Journal of Parasitology
J K Kloetzel, J J Lafaille

Abstract

Swiss albino, C57BL/10J, and B10.A mice previously inoculated with an LD50 dose of T. cruzi Y strain were protected against subsequent challenge with the homologous strain, but had a parasitemia comparable to that of control mice when challenged with F strain trypomastigotes, although they were protected against mortality. In contrast, animals previously inoculated with an LD50 of T. cruzi F strain were protected both against a subsequent challenge with the homologous strain and the Y strain.

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