PMID: 7542765Apr 1, 1995Paper

Strain variation limits protective activity of vaccines based on soluble Babesia canis antigens

Parasite Immunology
T P M SchettersH J Bos

Abstract

Groups of five dogs were immunized with vaccines containing soluble parasite antigens (SPA) derived from in vitro culture of Babesis canis parasites, either obtained commercially (Pirodog) or produced at laboratory scale. Both vaccines generated antibodies that reacted with parasitised erythrocytes (PE). Upon challenge infection with homologous parasites, protection was evident from less severe decreases of haematocrit values, and reduced morbidity. Vaccinated animals, however, were not protected against challenge infection with heterologous B. canis parasites. Recovery from challenge infection coincided with the production of antibodies against parasitized erythrocytes. The results suggest that SPA from B. canis carry strain-specific determinants that are crucial for inducing protection in dogs against challenge infection, and explain vaccination failures in the field.

References

Jan 1, 1989·The Veterinary Quarterly·G UilenbergA A Spanjer
Dec 1, 1995·Parasitology Today·T P Schetters, S Montenegro-James

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Citations

Dec 1, 1995·Parasitology Today·T P Schetters, S Montenegro-James
Sep 1, 1996·FEMS Immunology and Medical Microbiology·A W Cornelissen, T P Schetters
Mar 23, 2005·Trends in Parasitology·Theo Schetters
Feb 27, 1998·Veterinary Parasitology·T P SchettersD Goovaerts
May 12, 2009·Parasites & Vectors·Peter J Irwin
Jan 24, 2012·Trends in Parasitology·Vesna MatijatkoTheo P Schetters
Jul 20, 2010·Veterinary Parasitology·Patcharathorn SimkingSathaporn Jittapalapong
Oct 24, 2006·Veterinary Parasitology·Th P M SchettersA N Vermeulen
Mar 17, 2010·Journal of Veterinary Emergency and Critical Care·Ashley L AyoobJennifer Prittie
Jul 10, 2019·Trends in Parasitology·Vignesh RathinasamyBrian M Cooke

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