Strained ruthenium metal-organic dyads as photocisplatin agents with dual action

Journal of Inorganic Biochemistry
Tariq SainuddinSherri A McFarland

Abstract

Three strained Ru(II) metal-organic dyads were prepared and characterized by NMR, mass spectrometry, and analytical HPLC to probe whether these constructs could act as multifunctional photochemotherapy (PCT) agents. The compounds incorporated the crowded 6,6'-dimethyl-2,2'-bipyridine (6,6'-dmb) ligand to impart stoichiometric photocisplatin activity, and imidazo[4,5-f] [1,10]phenanthroline (IP) appended with n thiophene units (nT; n=1-3) to add capacity for singlet oxygen sensitization. With visible light activation, each complex of the series underwent rapid and selective photoejection of 6,6'-dmb in less than 10min, with half-lives (t1/2) as short as 46.3s for [Ru(6,6'-dmb)2(IP-1T)](2+). Photo-triggered ligand loss slowed with increasing n, and was slowest for [Ru(6,6'-dmb)2(IP-3T)](2+) (t1/2=273s). This trend also held for photoadduct formation with DNA; [Ru(6,6'-dmb)2(IP-1T)](2+) produced relaxed circular DNA at the lowest concentrations. Singlet oxygen yields (ΦΔ) increased with n, whereby ΦΔ for [Ru(6,6'-dmb)2(IP-1T)](2+) was only 3%, but increased to 42% on going to [Ru(6,6'-dmb)2(IP-3T)](2+). This photosensitization process was reflected by single-strand breaks in the gel-mobility shift assays of [Ru(6,6'-dmb)2(IP-3T)](...Continue Reading

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Citations

Jul 28, 2016·The Journal of Physical Chemistry. a·Christian ReichardtBenjamin Dietzek
Nov 25, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Koushambi Mitra
Jun 10, 2017·Chemical Communications : Chem Comm·Jordi-Amat Cuello-GariboSylvestre Bonnet
Jul 6, 2017·The Journal of Physical Chemistry. a·Christian ReichardtBenjamin Dietzek
Nov 28, 2017·Chemical Society Reviews·Fergus E PoyntonThorfinnur Gunnlaugsson
Apr 18, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Na TianQianxiong Zhou
Nov 7, 2019·Photochemistry and Photobiology·John RoqueSherri A McFarland
Jul 17, 2020·Chemical Communications : Chem Comm·Sandra Estalayo-AdriánThorfinnur Gunnlaugsson
Aug 8, 2020·Chemistry : a European Journal·Kilian R A SchneiderBenjamin Dietzek

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