PMID: 375237Mar 1, 1979Paper

Strand exchange in site-specific recombination

Proceedings of the National Academy of Sciences of the United States of America
L W EnquistR A Weisberg

Abstract

The site-specific recombination system of phage lambda promotes crossovers at its attachment site (att). In this report we show that when phage are crossed in conditions where only the site-specific recombination system is active, a low frequency of crossovers can also be detected in a region that is close to but does not contain att. These crossovers require the phage int gene, the host hip gene, and the integrity of att. They are not detected if one of the parents carries a substitution of a heterologous attachment site (attB instead of attP). To explain these findings we suggest that site-specific recombination can proceed by exchange of single strands between the participating chromosomes at att and migration of the resulting junction outside of att.

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Citations

Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·Y Kikuchi, H A Nash
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·H A NashJ F Gardner
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R HoessK Abremski
Aug 28, 2007·Nucleic Acids Research·Karolina MalanowskaJeffrey F Gardner
Jun 3, 2009·Microbiology and Molecular Biology Reviews : MMBR·Lara RajeevJeffrey F Gardner
Dec 14, 2004·Microbiology and Molecular Biology Reviews : MMBR·Max E Gottesman, Robert A Weisberg
May 25, 1985·Journal of Molecular Biology·A KikuchiR A Weisberg
Jun 1, 1982·Cell·K MizuuchiR A Weisberg
Jul 1, 1980·Cell·M P Calos, J H Miller
Feb 26, 2000·Annual Review of Genetics·R A WeisbergJ W Little
Sep 17, 2005·Progress in Nucleic Acid Research and Molecular Biology·Linda Lee, Paul D Sadowski
Sep 1, 1982·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·D Blöcher, W Pohlit
Nov 1, 1990·Journal of Bacteriology·R Nagaraja, R A Weisberg

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