Strand transfer to the 5' part of a tRNA as a mechanism for retrovirus patch-repair recombination in vivo

The Journal of General Virology
María L CarrascoF S Pedersen

Abstract

By screening for marker-cassette deletion mutants of a murine leukaemia virus-based replication-competent vector, two occurrences of tRNA sequence patch insertions were identified. In one of the cases, 28 nucleotides from the 5' end of tRNA(Lys4) were inserted in the plus-strand orientation, which points to a novel strand-transfer mechanism to tRNAs during reverse transcriptase-mediated retroviral recombination.

References

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Citations

May 4, 2006·Nucleic Acids Research·Pavlina KonstantinovaBen Berkhout

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